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Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.
TLDR
Data to the authors' knowledge provide the first direct evidence that the anabolic effects of PTH on bone formation in vivo require IGF-I action in growing mice.
Factors related to long-term outcome after decompressive surgery for ossification of the ligamentum flavum of the thoracic spine.
TLDR
The duration of preoperative symptoms represents the most important predictor of long-term surgery-related outcome in patients treated for thoracic OLF and the type of ossified ligamentum flavum, dural adhesion, and simultaneous surgery for coexistent cervical or lumbar lesions do not appear to influence the long- term postoperative prognosis.
Evidence that IGF-binding protein-5 functions as a growth factor.
TLDR
In vitro and in vivo effects of IGFBP-5 on bone formation parameters using the IGF-I knockout mouse provide the first direct evidence to the authors' knowledge that IGF BP-5 functions as a growth factor that stimulates its actions in part via an IGF-independent mechanism.
Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide
TLDR
TPTD treatment appears to significantly shorten the postoperative time to fracture healing and reduce rates of delayed healing or non-union after bisphosphonate-associated AFF.
A Missense Mutation in the Mouse Col2a1 Gene Causes Spondyloepiphyseal Dysplasia Congenita, Hearing Loss, and Retinoschisis
TLDR
A missense mutation in the mouse Col2a1 gene has been discovered, resulting in a mouse phenotype with similarities to human spondyloepiphyseal dysplasia (SED) congenita, which offers a useful tool for molecular and biological studies of bone development and pathology.
Systemic administration of insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) increases bone formation parameters in mice by increasing IGF bioavailability via an IGFBP-4 protease-dependent
TLDR
It is demonstrated that systemic administration of IGFBP-4 increases bone formation parameters in mice by increasing IGF bioavailability in the circulation via an IGF BP-4 protease-dependent mechanism.
Postnatal and Pubertal Skeletal Changes Contribute Predominantly to the Differences in Peak Bone Density Between C3H/HeJ and C57BL/6J Mice
TLDR
The hypothesis that the greater amount of bone accrued during postnatal and pubertal growth in C3H mice compared with B6 mice may be caused by increased cortical thickness, increased endosteal bone formation, and decreased endostealing bone resorption is supported.
The anabolic effects of GH/IGF system on bone.
TLDR
Osteoporosis is the result of imbalance in bone remodeling caused by increased bone resorption and decreased bone formation, and a deficiency in growth hormone (GH)/insulin-like growth factor (IGF) system that occurs with age has been proposed to play a major role.
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