• Publications
  • Influence
Tolerance and autoimmunity.
TLDR
Tolerance is the process that eliminates or neutralizes such autoreactive cells, and a breakdown in the working of this system can cause autoimmunity.
The carrier effect in the secondary response to hapten‐protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis
  • N. Mitchison
  • Biology, Medicine
    European journal of immunology
  • 1971
A carrier effect is obtained typically when a hapten‐protein conjugate is injected into an animal which has previously been primed with the same hapten conjugated to another carrier protein. Under
The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation
  • N. Mitchison
  • Biology, Medicine
    European journal of immunology
  • 1971
TLDR
The adoptive secondary response of mice to conjugates of NIP and DNP is used to elucidate the mechanism of cellular cooperation and shows that helper cells serve a role as handlers or concentrators of antigen, thus enabling AFCP which would otherwise be incapable of reacting to initiate antibody synthesis.
Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds.
TLDR
Primary immunization is obtained more efficiently with alum-precipitated conjugates mixed with pertussis, than with Conjugates alone or in Freund's complete adjuvant, and is most efficient with conjugate of chicken serum globulin (NIP—CG) or edestin.
STUDIES ON THE IMMUNOLOGICAL RESPONSE TO FOREIGN TUMOR TRANSPLANTS IN THE MOUSE
TLDR
The conclusion is drawn that the hemagglutinating antibody is distinct from the antibody effective in combating homografts.
Passive Transfer of Transplantation Immunity
TLDR
A simple procedure for passively transferring transplantation immunity to a tumour is reported.
Immunologic approach to cancer.
Mathematical models in immunology
Theoretical Immunology.Edited by G. I. Bell, A. S. Perelson and G. H. Pimbley Jr. (Marcel Dekker: New York and Basel, 1978.) Sfr. 128.
The mechanism of immunological paralysis.
TLDR
This chapter presents the mechanism of immunological paralysis and focuses on protein antigens, particularly heterologous serum proteins, of special interest because of their application in exploring the induction of paralysis in adult animals by low doses.
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