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cDNA nucleotide sequence and primary structure of mouse uterine peptidylarginine deiminase. Detection of a 3'-untranslated nucleotide sequence common to the mRNA of transiently expressed genes and…
- M. Tsuchida, H. Takahara, +5 authors K. Sugawara
- Biology, Medicine
- European journal of biochemistry
- 1 August 1993
Peptidylarginine deiminase is a protein-modulating enzyme which converts the arginine residues in proteins to citrulline residues. This study describes the complete primary structure of mouse… Expand
Synthesis of 4-(methoxyethyl) monobactams by a chemicoenzymatic approach.
As a key intermediate for the synthesis of monobactam analogues, cis-3-benzyloxycarbonyl-amino-4-(2-hydroxyehtyl)-2-azetidinone was synthesized from (4S)-4-methoxycarbonylmethyl-2-azetidinone, and… Expand
Studies on Ketene and Its Derivatives. XLVIII. Reaction of Diketene with Hydroxylamine
Studies on Agents with Vasodilator and β-Blocking Activities. I
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of… Expand
Studies on the synthesis of sesquiterpene lactones, 16. The syntheses of 11 beta, 13-dihydrokauniolide, estafiatin, isodehydrocostuslactone, 2-oxodesoxyligustrin, arborescin, 1,10-epiarborescin, 11…
Synthesis of 4-(Methoxyethyl) Monobactams by a Chemicoenzymatic Approach.
9,10-dihydroanthracene-2-alkanoic acid derivative
NEW MATERIAL:9,10-Dihydroanthracene-2-alkanoic acids of formula I (Y is C= O or CH 2 ; R 1 is H or lower alkyl), and their salts, esters and amide derivatives. EXAMPLE: Methyl… Expand
2-formyldibenzazepin derivative and its preparation
NEW MATERIAL:2-Formyldibenzazepin derivative of formula I (R 1 is lower alkyl or aralkyl; R 2 is H or halogen). EXAMPLE: 2-Formyl-5,6-dihydro-5-methyl-11-oxodibenz[b,e]azepin. USE: Intermediate of… Expand
【課題】ｐ３８ＭＡＰキナーゼ阻害作用及びそれに基づくＴＮＦ−α、ＩＬ−１、ＩＬ−６、ＣＯＸ−ＩＩ等の産生阻害作用を有しており、ＴＮＦ−α関連疾患、ＩＬ−１関連疾患、ＩＬ−６関連疾患又はＣＯＸ−ＩＩ関連疾患等の治療剤として有用な化合物の提供。 【解決手段】本発明は、式 【化１】 式中、 Ｑは置換されていてもよいアリール基等を表わし、 Ｒ １ は水素原子、低級アルコキシ基等を表わし、 Ｒ ２… Expand
NEW MATERIAL:1-Phenylisoquinoline derivatives of formula I (R 1 is H, lower alkyl; R 2 is H, halogen, lower alkoxy; Y is carboxyl, cyano) and their salts. EXAMPLE: 1-Phenylisoquinolin-5-ylacetic… Expand