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Resistance training and redox homeostasis: Correlation with age-associated genomic changes
Regular physical activity is effective as prevention and treatment for different chronic conditions related to the ageing processes. In fact, a sedentary lifestyle has been linked to a worsening ofExpand
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Exercise-induced ROS in heat shock proteins response.
Cells have evolved multiple and sophisticated stress response mechanisms aiming to prevent macromolecular (including proteins, lipids, and nucleic acids) damage and to maintain or re-establishExpand
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AlphaB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts.
Recent studies suggest that the effects of VEGF-A, the prototype VEGF ligand, may extend to a variety of cell types other than endothelial cells. The expression of VEGF-A and its main receptors,Expand
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Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training
Reactive oxygen and nitrogen species are important signal molecules for adaptations to training. Due to the antioxidant properties of vitamin C and E, supplementation has been shown to bluntExpand
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MicroRNAs as Multifaceted Players in Glioblastoma Multiforme.
Glioblastoma multiforme (GBM) is the most common and inevitably lethal primary brain tumor, with a median survival rate of only 15 months from diagnosis. The current standard treatment involvesExpand
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The role of αB-crystallin in skeletal and cardiac muscle tissues
All organisms and cells respond to various stress conditions such as environmental, metabolic, or pathophysiological stress by generally upregulating, among others, the expression and/or activationExpand
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Regulation of the p 27 Kip 1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
Carlos le Sage, Remco Nagel, David A Egan, Mariette Schrier, Elly Mesman, Annunziato Mangiola, Corrado Anile, Giulio Maira, Neri Mercatelli, Silvia Anna Ciafrè, Maria Giulia Farace and Reuven Agami*Expand
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Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response
Abstract The multiple roles that have been associated with heat shock proteins (HSPs), inside and outside cells are remarkable. HSPs have been found to play a fundamental role in multiple stressExpand
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Physical activity in the prevention of human diseases: role of epigenetic modifications
Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigeneticExpand
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MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation
Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing protein involved in cellular redox homeostasis which is downregulated in skeletal muscle differentiation. Here we show that TrxR1Expand
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