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Photoreceptor loss in age-related macular degeneration.
PURPOSE The authors showed previously that parafoveal rods, but not cones, decrease during the course of adulthood in donor eyes that were screened to exclude the grossly visible macular drusen andExpand
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Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy.
To address the potential for an outer segment (OS) contribution to the sub-retinal pigment epithelium (RPE) lesions of age-related maculopathy (ARM), we quantified esterified and unesterifiedExpand
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Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy.
In geographic atrophy (GA), the non-neovascular end stage of age-related macular degeneration (AMD), the macular retinal pigment epithelium (RPE) progressively degenerates. Membrane cofactor proteinExpand
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Preservation of ganglion cell layer neurons in age-related macular degeneration.
PURPOSE To determine the number of neurons remaining in the ganglion cell layer (GCL) of eyes with nonexudative and exudative age-related macular degeneration (NEAMD and EXAMD, respectively) inExpand
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The Alabama Age-Related Macular Degeneration Grading System for donor eyes.
PURPOSE To develop a systematic method for identifying and grading age-related macular degeneration (ARMD) in human donor eyes, postmortem fundus appearance was compared with histopathologicExpand
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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy.
Lipids accumulate in Bruch's membrane (BrM), a specialized vascular intima of the eye, and in extracellular lesions associated with aging and age-related maculopathy (ARM). We tested the hypothesisExpand
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Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy.
The principal extracellular lesions of age-related maculopathy (ARM), the leading cause of vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between the retinalExpand
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SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Morphology, Prevalence, Topography, and Biogenesis Model
Purpose: To characterize the morphology, prevalence, and topography of subretinal drusenoid deposits, a candidate histological correlate of reticular pseudodrusen, with reference to basal linearExpand
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Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy.
PURPOSE Macular drusen are hallmarks of age-related maculopathy (ARM), but these focal extracellular lesions also appear with age in the peripheral retina. The present study was conducted toExpand
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Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles.
Neutral lipid, including esterified cholesterol, and apolipoproteins B and E are abundant in basal deposits and drusen of aged and age-related maculopathy (ARM) eyes. The principal component of basalExpand
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