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NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice
- E. Kroon, U. Thorsteinsdottir, N. Mayotte, T. Nakamura, G. Sauvageau
- Medicine, Biology
- The EMBO journal
- 1 February 2001
Here we describe hemopoietic chimeras serving as a mouse model for NUP98–HOXA9‐induced leukemia, which reproduced several of the phenotypes observed in human disease. Mice transplanted with bone… Expand
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.
In this study, we describe an in vivo RNA interference functional genetics approach to evaluate the role of 20 different conserved polarity factors and fate determinants in mouse hematopoietic stem… Expand
Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
Human adult stem cell expansion Transfused blood saves lives. Despite the widespread use of this critical resource, it is difficult to increase blood cell numbers outside of the body. By screening… Expand
A role for GPx3 in activity of normal and leukemia stem cells
- O. Hérault, K. Hope, +8 authors G. Sauvageau
- Medicine, Biology
- The Journal of experimental medicine
- 7 May 2012
High levels of glutathione peroxidase 3 (GPx3) expression correlate with adverse prognosis in acute myeloid leukemia, and enhance activity of long-term repopulating hematopoietic stem cells in mice.
RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.
Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain-containing family of demethylases comprises 27 members that target… Expand
Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.
The Hoxa9 and Meis1 genes represent important oncogenic collaborators activated in a significant proportion of human leukemias with genetic alterations in the MLL gene. In this study, we show that… Expand
A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity
Despite tremendous progress made toward the identification of the molecular circuitry that governs cell fate in embryonic stem cells, genes controlling this process in the adult hematopoietic stem… Expand
EPCR expression marks UM171-expanded CD34+ cord blood stem cells.
A small subset of human cord blood CD34+ cells express endothelial protein C receptor (EPCR/CD201/PROCR) when exposed to the hematopoietic stem cell (HSC) self-renewal agonist UM171. In this article,… Expand
E4F1 is a master regulator of CHK1-mediated functions.
It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system. Here, we report that E4f1 is essential for hematopoietic cell… Expand
The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential.
We previously showed that HOXB4 is a potent stimulator of hematopoietic stem cell (HSC) proliferation in vivo and ex vivo. As a result, HOXB4 overexpressing HSCs are 20- to 50-times more competitive… Expand