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Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1.
TC is the most specific PP1 inhibitor out of over 40 species of natural phosphatase inhibitors reported, strongly suggesting that TC is a novel powerful tool to elucidate the physiological roles of PP1 in various biological events. Expand
Screening System for the Maillard Reaction Inhibitor from Natural Product Extracts
An assay for the Maillard reaction has been developed to screen efficiently inhibitors from natural resources such as extracts of plants. The fluorometric analysis of fluorescent material based onExpand
Usage of Tautomycetin, a Novel Inhibitor of Protein Phosphatase 1 (PP1), Reveals That PP1 Is a Positive Regulator of Raf-1 in Vivo *
Using TC as a specific PP1 inhibitor, the biological effect of PP1 on MAPK signaling was examined and it was found that inhibition ofPP1 in COS-7 cells by TC specifically suppresses activation of ERK, among three MAPK kinases (ERK, JNK, and p38). Expand
Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.
It is suggested that preconditioning by sesquiterpene lactone may enhance activation of the Nrf2/ARE pathway and induction of phase II detoxification/antioxidant enzymes upon oxidative stress, thereby resulting in increased resistance to oxidative damage. Expand
Antioxidant Activity of Hydroxyflavonoids
The antioxidant activity of 28 natural and synthetic hydroxyflavonoids was estimated through the 1,1-diphenyl-2-picrylhyrazyl (DPPH) radical, superoxide scavenging activities and lipid peroxidationExpand
Isoflavones from stems of Euchresta horsfieldii
Four new prenyl(=3-methyl-2-butenyl)isoflavones, euchrenones b6-b9, were isolated from stems of Euchresta horsfieldii from Thailand and 1H NMR spectral properties of regio-isomers, such as warangalone and osajin, are discussed. Expand
Pauferrol A, a novel chalcone trimer with a cyclobutane ring from Caesalpinia ferrea mart exhibiting DNA topoisomerase II inhibition and apoptosis-inducing activity
Abstract Pauferrol A ( 1 ), a unique chalcone derivative was isolated from the stems of Caesalpinia ferrea Mart, and the structure was determined on the basis of 2D-NMR spectroscopy to be a chalconeExpand
Germacranolides from Calea urticifolia.
Four germacranolides were isolated from the leaves of Calea urticifolia, and calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells. Expand
Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
Results indicate that germacranolides isolated from Calea urticifolia are the specific inhibitors of preadipocyte differentiation. Expand
γ-Mangostin from Garcinia Mangostana Pericarps as a Dual Agonist That Activates Both PPARα and PPARδ
We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstratedExpand