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Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor δ-Selective Agonists in Vitro and in Vivo
TLDR
It is demonstrated that subtype-selective PPARδ agonists possess antiapoptotic properties in vitro, which may underlie their potential neuroprotective potential in in vivo experimental models of cerebral ischemia and Parkinson's disease (PD).
Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice
TLDR
A clear difference between GSI and GSM in effects on functional consequences is demonstrated, providing new insights into strategies for developing these drugs against Alzheimer's disease.
Stress increases plasma enzyme activity in rats: differential effects of adrenergic and cholinergic blockades.
TLDR
Excessive peripheral sympathetic activity possibly plays an important role in the water immersion stress-induced increases in the plasma enzymes activity primarily via beta-adrenoceptors and the cholinergic nerves, whereas alpha- adrenoceptor networks might be involved in the stress- induced increases in plasma urea nitrogen and glucose levels.
Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect
TLDR
The results suggest that blockage of the TRPV1 receptor without affecting the proton-mediated TRpV1 activation is a promising approach to treating neuropathic pain because of the potential wide safety margin against hyperthermic effects.
Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in
TLDR
It is shown that prevention of PARP activation by FR255595 protects against both ROS-induced cells injury in vitro and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal dopaminergic damage in an in vivo Parkinson's disease (PD) model, suggesting that the drug could be an attractive candidate for several neurodegenerative disorders, including PD.
FK1706, a novel non-immunosuppressive immunophilin: neurotrophic activity and mechanism of action.
Peg3/Pw1 Is Involved in p53-mediated Cell Death Pathway in Brain Ischemia/Hypoxia*
TLDR
It is found that Peg3/Pw1 expression is enhanced in peri-ischemic neurons in rat stroke model by in situ hybridization analysis, where p53 expression was also induced by immunohistochemical analysis, and p53 was co-localized with Peg3 or Pw1 in brain ischemia/hypoxia by double staining analysis.
A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in
TLDR
It is shown that prevention of PARP activation by FR247304 treatment protects against both reactive oxygen species-induced PC12 cell injury in vitro and ischemic brain injury in vivo and also suggests that FR 247304 or its derivatives could be attractive therapeutic candidates for stroke and neurodegenerative disease.
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