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The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.
Hydrogen sulfide (H2S), which is well known as a toxic gas, is produced endogenously in mammalian tissues from L-cysteine mainly by two pyridoxal-5'-phosphate-dependent enzymes, cystathionineExpand
Inhibition of GABAA Synaptic Responses by Brain-Derived Neurotrophic Factor (BDNF) in Rat Hippocampus
TLDR
The data suggest that BDNF modulates GABAA synaptic responses by postsynaptic activation of Trk-type receptor and subsequent Ca2+mobilization in the CNS. Expand
Locally Synchronized Synaptic Inputs
TLDR
Clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration. Expand
Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo
TLDR
Almost all astrocytes participated en masse in regenerative waves that propagated from cell to cell (referred to here as “glissandi”) and emerged depending on the neuronal activity and accompanied a reduction in infraslow fluctuations of local field potentials and a decrease in the flow of red blood cells. Expand
Brain-Derived Neurotrophic Factor Promotes the Maturation of GABAergic Mechanisms in Cultured Hippocampal Neurons
TLDR
It is shown that BDNF facilitates high K+-elicited release of GABA but not of glutamate and induces an increase in immunoreactive signals of glutamic acid decarboxylase, a GABA-synthesizing enzyme, which indicates that it principally promotes GABAergic maturation but may also potentially contribute to excitatory synapse development via increasing resting synaptic vesicles. Expand
Activity-Evoked Capacitative Ca2+ Entry: Implications in Synaptic Plasticity
TLDR
Using Ca2+ imaging, evidence is presented for the presence of SOC in cultured hippocampal pyramidal neurons and a novel link between ionotropic receptor-activated SOC and neuroplasticity is suggested. Expand
Activity-Dependent Proteolytic Cleavage of Neuroligin-1
TLDR
It is reported that neuroligin-1 (NLG1) undergoes ectodomain shedding at the juxtamembrane stalk region to generate a secreted form of NLG1 and a membrane-tethered C-terminal fragment (CTF) in adult rat brains in vivo as well as in neuronal cultures. Expand
Action-Potential Modulation During Axonal Conduction
TLDR
The waveform of an action potential can be physiologically modified while it travels along the axon, and this local AP modification may enable axonal computation through the geometry of axon wiring. Expand
Laminin Degradation by Plasmin Regulates Long-Term Potentiation
TLDR
The results suggest that the laminin-mediated cell–ECM interaction may be necessary for the maintenance of LTP and that the PA–plasmin system regulates synaptic plasticity. Expand
Fast and accurate detection of action potentials from somatic calcium fluctuations.
TLDR
A novel automatic method is described that combines principal-component analysis and support vector machine that determines the timings of the spikes in calcium fluorescence traces more rapidly and reliably than human operators. Expand
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