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Early Changes in KCC2 Phosphorylation in Response to Neuronal Stress Result in Functional Downregulation
TLDR
It is proposed that neuronal stress induces a rapid loss of tyrosine phosphorylation of KCC2 that results in translocation of the protein and functional loss of transport activity and may provide means for manipulating the extent of irreversible injury resulting from different neuronal stressors.
Transplantation of Human Neural Stem Cells Exerts Neuroprotection in a Rat Model of Parkinson's Disease
TLDR
Results suggest that HB1.F3 cell transplantation exerts neuroprotective effects against dopaminergic depletion in vitro and in vivo because of trophic factor secretion and neuronal differentiation.
Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
TLDR
The utility of blood–brain barrier permeabilization in facilitating cell therapy for treating neonatal HI injury is extended, showing that HI animals that received HUCB cells alone or when combined with mannitol were significantly less impaired in motor asymmetry and motor coordination compared with those that received vehicle alone orMannitol alone.
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
TLDR
The data indicate that the neuroprotection is dose-dependent, in that only low dose minocycline inhibits neuronal cell death cascades at the acute stroke phase, whereas the high dose exacerbates the ischemic injury.
Hippocampal cholinergic neurostimulating peptides (HCNP)
Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital
An unusual course of progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia
TLDR
This is the first patient with CD4+T lymphocytopenia with progressive multifocal leukoencephalopathy, suggesting that similar opportunistic infections should be considered even in previously normal people.
Lactobacillus in Jelly Enhances the Effect of Influenza Vaccination in Elderly Individuals
TLDR
New ischemic events and valve disease progression were more predictive of CHF decompensation in younger than in older participants, and multiple identified factors were present in almost half of the older participants in the current study, indicating that comorbidities may play an important role in CHF decomensation in older adults.
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