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Early Changes in KCC2 Phosphorylation in Response to Neuronal Stress Result in Functional Downregulation
The K+ Cl− cotransporter KCC2 plays an important role in chloride homeostasis and in neuronal responses mediated by ionotropic GABA and glycine receptors. The expression levels of KCC2 in neuronsExpand
Transplantation of Human Neural Stem Cells Exerts Neuroprotection in a Rat Model of Parkinson's Disease
Neural stem cells (NSCs) possess high potencies of self-renewal and neuronal differentiation. We explored here whether transplantation of human NSCs cloned by v-myc gene transfer, HB1.F3 cells, is aExpand
Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
Age-dependent increase of peroxidation of membrane fatty acids such as arachidonic acid (ARA) and docosahexaenoic acid (DHA) in neurons was reported to cause a decline of the hippocampal long-termExpand
Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts
We recently demonstrated that blood–brain barrier permeabilization using mannitol enhances the therapeutic efficacy of systemically administered human umbilical cord blood (HUCB) by facilitating theExpand
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
BackgroundMinocycline, a second-generation tetracycline with anti-inflammatory and anti-apoptotic properties, has been shown to promote therapeutic benefits in experimental stroke. However, equallyExpand
Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies
Objective To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularlyExpand
Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis
Bedridden patients who receive good physical rehabilitation are able to exhibit clinical improvement. Accumulating evidence demonstrates that exercise increases endogenous neurogenesis and may evenExpand
An unusual course of progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia
A case is reported of idiopathic CD4+T lymphocytopenia with progressive multifocal leukoencephalopathy and cervical lymph node tuberculosis. A 57 year old Japanese man presented with cervicalExpand
Subthalamic nucleus stimulation for Parkinson disease with severe medication-induced hallucinations or delusions.
OBJECT Subthalamic nucleus deep brain stimulation (STN DBS) improves cardinal motor symptoms of Parkinson disease (PD) and reduces antiparkinsonian medication. Therefore, STN DBS seems to be wellExpand
Lactobacillus in Jelly Enhances the Effect of Influenza Vaccination in Elderly Individuals
dictors of CHF decompensation were infections (hazard ratio (HR) = 4.74, 95% confidence interval (CI) = 2.80– 7.51, P < .01) and arrhythmias (HR = 3.85, 95% CI = 1.94–5.41, P < .001), whereas inExpand