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Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target
TLDR
Despite their hyperplastic growth, Cdk4R24C insulin-producing islet cells behave like differentiated beta cells with regard to insulin production, insulin secretion in response to glucose, and islet glucose metabolism, therefore Cdk 4 could possibly be used to engineer a source of beta cell mass for islet transplantation. Expand
Quantitative Determination of Relevant Amounts of Blood Coagulation Factor XI Activity in a Specific Brand of Intravenous Immunoglobulin
Background: Residual content of activated procoagulant components, particularly FXIa, has been suggested to play a relevant role in the increased thrombogenic potential of intravenous immunoglobulinExpand
Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells.
TLDR
Although no effect was observed in glucose-induced insulin secretion, it is found that tungstate activates basal insulin release, a process driven, at least in part, by activation of p38. Expand
Cyclin-Dependent Kinase 4 Hyperactivity Promotes Autoreactivity in the Immune System but Protects Pancreatic β Cell Mass from Autoimmune Destruction in the Nonobese Diabetic Mouse Model1
TLDR
The Cdk4R24C mutation opens two avenues in the NOD model: when expressed specifically in β cells, it provides a new potential strategy for β cell regeneration in autoimmune diabetes, but its expression in the immune repertoire exacerbates autoimmunity. Expand
Pasteurization Inactivates Clotting Enzymes During Flebogamma And Flebogamma DIF Production
TLDR
Pasteurisation step of the Flebogamma and Flebogsamma DIF production process inactivates clotting (pro)enzymes and coagulation factor activation markers. Expand
Flebogamma(®) DIF (intravenous immunoglobulin) purification process effectively eliminates procoagulant activities.
TLDR
The Flebogamma(®) DIF production process is capable of eliminating procoagulant activity because of its purification steps. Expand
Hyperimmune immunoglobulins: Manufacturing technologies and safety procedures
TLDR
The stability profile indicates that the products are stable between 2°C and 8°C for two years (Gamma anti-hepatitis B Grifols®) or three years (Niuliva®), maintaining the anti-HB potency. Expand
Characterization of antibodies in human immunoglobulin products from different regions worldwide
TLDR
The antibody profile in IVIG was greatly influenced by regional characteristics including climate, vaccination programs and prevalence of pathogens in the different countries and regions. Expand
119 Effect of Unconjugated Bilirubin on Intestinal Permeability and Fecal Calprotectin in Healthy Term Newborns.
TLDR
This direct damage to the small intestine mucosa, expose these healthy term newborns at many risks due to a facilitate passage of food allergens or bacterial antigens through the intestinal epithelial barrier. Expand