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Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP
TLDR
It is proposed that Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex, and that Src phosphorylated terminates cortact in activation of N-wASP and WASP. Expand
WIP regulates N-WASP-mediated actin polymerization and filopodium formation
TLDR
It is shown that WASP-interacting protein (WIP) interacts directly with N-WASP and actin, which is consistent with their role in actin-tail formation in cells infected with vaccinia virus or Shigella. Expand
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac‐mediated actin‐based motility
TLDR
A non‐redundant role for WAVE2 in murine embryogenesis and a critical role in actin‐based processes downstream of Rac that are essential for cell movement are implied. Expand
The Human WASP-interacting Protein, WIP, Activates the Cell Polarity Pathway in Yeast*
TLDR
A role for WIP in cell polarity provides a framework for unifying, under a common paradigm, distinct molecular defects associated with immunodeficiencies like Wiskott-Aldrich syndrome. Expand
Diploid expression of human leukocyte antigen class I and class II molecules on spermatozoa and their cyclic inverse correlation with inhibin concentration.
TLDR
Observations could put to an end a disconcerting and long-lasting controversy on the expression/non-expression of HLA antigens on spermatozoa. Expand
The contribution of the HLA-A, -B, -C and -DR, -DQ DNA typing to the study of the origins of Spaniards and Basques.
TLDR
HLA genetic distances and their respective dendrogram together with the results on complete HLA haplotypes place Basques and Spaniards closer to paleo-North African populations than to other Europeans, going in favour of the Basques being a relative genetic isolate coming from the primitive Iberian/paleo- North African people. Expand
HLA DR and DQ polymorphism in Ashkenazi and non-Ashkenazi Jews: comparison with other Mediterraneans.
TLDR
Allele frequencies, characteristic DR/DQ linkage disequilibria, population distances and their corresponding dendrogram by using the Neighbor-Joining method were used to study relatedness between Jewish and other Mediterranean and non Mediterranean populations. Expand
Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori.
TLDR
It is proposed that Hp targets cortactin to protect the gastric epithelium from excessive cell lifting and ensure sustained infection in the stomach and unravels a previously unrecognized FAK activation pathway. Expand
Waltzing with WASP.
TLDR
The authors discuss the possible role of WASP/NWASP and of the newly described protein WIP, which interacts with WASP and NWASP, in coupling signals from the T-cell receptor to the actin-based cytoskeleton. Expand
Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP
TLDR
It is proposed that cortactin binds Tir through its N-terminal part in a tyrosine and serine phosphorylation independent manner while SH3 domain binding and activation of N-WASP is regulated by tyrosines and serines mediatedosphorylation of cortactIn. Expand
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