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Heritability of human cranial dimensions: comparing the evolvability of different cranial regions
TLDR
Previous findings in the mouse cranium are supported and empirical evidence that covariation between the maximum widths of the main developmental regions of the skull is the dominant factor of integration in the human skull is provided.
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Functional-cranial approach to the influence of economic strategy on skull morphology.
TLDR
Results demonstrate that the environmental factors studied likely influenced the masticatory component's size and shape, and provides interesting clues to localize plastic or adaptive responses to external stimuli.
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Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2+P253R mice
TLDR
In vivo studies demonstrated that the Fgfr2 +/P253R mutation resulted in mice with cranial features that resemble those of the F gfr2+/S252Wmice and human Apert syndrome.
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Lack of Support for the Association between Facial Shape and Aggression: A Reappraisal Based on a Worldwide Population Genetics Perspective
TLDR
It is shown that 4,960 individuals from 94 modern human populations belonging to a vast array of genetic and cultural contexts do not display significant amounts of fWHR sexual dimorphism, and that sexual selection was weak enough to leave a signal on patterns of between- and within-sex and population facial variation.
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The influence of masticatory loading on craniofacial morphology: A test case across technological transitions in the Ohio valley.
TLDR
An extinct human population from the middle and upper Ohio valley that underwent a marked shift from hunting-gathering to extensive farming during the last 3,000 years is tested, highlighting the utility of exploring specific localized morphological shifts using a hierarchical model of craniofacial integration.
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Phenotypic evolution of human craniofacial morphology after admixture: a geometric morphometrics approach.
TLDR
Results obtained after the craniofacial analysis are in accordance with previous molecular and historical interpretations, providing evidence that admixture is a main microevolutionary agent influencing modern Mexican gene pool.
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Cultural diversification promotes rapid phenotypic evolution in Xavánte Indians
TLDR
It is shown that quantitative genetic parameters obtained from cephalometric data taken on 1,203 individuals analyzed in combination with genetic, climatic, social, and life-history data belonging to six South Amerindian populations are compatible with a scenario of rapid genetic and phenotypic evolution, probably mediated by cultural shifts.
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PERVASIVE GENETIC INTEGRATION DIRECTS THE EVOLUTION OF HUMAN SKULL SHAPE
TLDR
The results indicate pervasive integration in the human skull and suggest a reinterpretation of the selective scenario for human evolution where the origin of any one of the derived characters may have facilitated the evolution of the others.
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FGF/FGFR Signaling Coordinates Skull Development by Modulating Magnitude of Morphological Integration: Evidence from Apert Syndrome Mouse Models
TLDR
Although Fgfr2 mutations do not disrupt skull MI, FGF/FGFR signaling is a covariance-generating process in skull development that acts as a global factor modulating the intensity of MI, indicating that this pathway evolved early in vertebrate evolution and may have played a significant role in establishing the patterns of skull MI and coordinating proper skull development.
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Developmental and Genetic Constraints on Neurocranial Globularity: Insights from Analyses of Deformed Skulls and Quantitative Genetics
TLDR
The results indicate that putative developmental constraints help to preserve some aspects of normal morphological integration even in the deformed skulls and find that the response to selection in neurocranial globularity is pervasive, indicating that departures from normal patterns of neuroc Cranial Globularity are genetically constrained.
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