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A Short History Of Nitroglycerine And Nitric Oxide In Pharmacology And Physiology
1. Nitroglycerine (NG) was discovered in 1847 by Ascanio Sobrero in Turin, following work with Theophile‐Jules Pelouze. Sobrero first noted the ‘violent headache’ produced by minute quantities of NGExpand
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Snake venoms affecting the haemostatic mechanism--a consideration of their mechanisms, practical applications and biological significance.
  • N. Marsh
  • Chemistry, Medicine
  • Blood coagulation & fibrinolysis : an…
  • 1 June 1994
Snake venoms contain a rich variety of factors affecting the haemostatic mechanism which can be broadly classified as possessing coagulatant, anticoagulant and haemorrhagic activity. CoagulantExpand
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The Gaboon viper (Bitis gabonica): its biology, venom components and toxinology.
The Gaboon viper has acquired an impressive reputation which is at least partly unfounded. This handsome animal with such striking features is undoubtedly docile which accounts for the very lowExpand
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The Gaboon viper, Bitis gabonica: hemorrhagic, metabolic, cardiovascular and clinical effects of the venom.
The effects of Bitis gabonica venom have been studied in several animal species, including the monkey, dog, rabbit, rat and guinea pig. Further information has been provided by observations on theExpand
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Separation and Partial Characterization of a Coagulant Enzyme from Bitis gabonica Venom
Summary. The venom of the Gaboon viper (Bitis gabonica) has been shown to possess both coagulant and anticoagulant activities in vitro. These findings confirm in part previous results, the latterExpand
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New insights into nitric oxide and coronary circulation.
Since its discovery over 20 years ago as an intercellular messenger, nitric oxide (NO), has been extensively studied with regard to its involvement in the control of the circulation and, moreExpand
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Isolation and partial characterization of a prothrombin-activating enzyme from the venom of the Australian rough-scaled snake (Tropidechis carinatus).
A prothrombin activator from the venom of Tropidechis carinatus has been isolated by means of gel filtration and benzamidine-based affinity chromatography, a novel use of the latter technique. TwoExpand
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The factor V HR2 haplotype: prevalence and association of the A4070G and A6755G polymorphisms
Recently, a polymorphism was identified in exon 25 of the factor V gene that is possibly a functional candidate for the HR2 haplotype. This haplotype is characterized by a single base substitutionExpand
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The mechanical effects of rhinoceros horned viper (Bitis nasicornis) venom on the isolated perfused guinea‐pig heart
In the guinea‐pig Langendorff heart preparation, addition of 0.1 mg Bitis nasicornis venom to the perfusion solution caused transient increases in heart rate (HR) and left ventricular systolicExpand
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The accelerating effect of fibrinogen and early fibrinogen degradation products on erythrocyte sedimentation.
  • N. Marsh
  • Chemistry, Medicine
  • Thrombosis and haemostasis
  • 31 August 1979
The fibrinogen molecule has a number of biological activities and some of these are shared by the larger degradation products. This study was carried out to investigate the erythrocyteExpand
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