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RNAi Effector Diversity in Nematodes
While RNA interference (RNAi) has been deployed to facilitate gene function studies in diverse helminths, parasitic nematodes appear variably susceptible. To test if this is due to inter-speciesExpand
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
The data reveal that nematode FLPs encompass the most complex neuropeptide family known within the metazoa, and individual FLPs and FLP motifs are highly conserved across the nematodes with little evidence for inter-clade or inter-lifestyle variation, supporting their fundamental role in free-living and parasitic species. Expand
The FLP-side of nematodes.
Current knowledge of nematode FLP signalling is summarized and much work is needed to clarify the functional aspects of FLPs and how these peptides exert their effects at the organismal level. Expand
The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration.
The successful silencing of the cysteine proteases cathepsin B and L in the infective stage of Fasciola hepatica newly excysted juveniles (NEJs) resulted in marked reductions in target transcript levels and significant diminution in the encoded proteins in the gut. Expand
Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology
Part I: Phylogeny, Genetics and Transcriptomes * The Evolution of Parasitism in Flatworms * Genomes and Genomics of Parasitic Flatworms. Expand
Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips fromAscaris suum
It is shown that the effects of PF1 were also dependent on external Ca++ and were reduced by the Ca++-channel blocker verapamil, observations consistent with the finding that nematode NOS is Ca++/Ca++-dependent. Expand
Terminal Nerve-Derived Neuropeptide Y Modulates Physiological Responses in the Olfactory Epithelium of Hungry Axolotls (Ambystoma mexicanum)
It is found that axolotl NPY modulates olfactory epithelial responses evoked by l-glutamic acid, a food-related odorant, but only in hungry animals, and whole-cell patch-clamp recordings demonstrate that bath application of axolotor NPY enhances the magnitude of a tetrodotoxin-sensitive inward current, butonly in hungryAnimals. Expand
The musculature and associated innervation of adult and intramolluscan stages of Echinostoma caproni (Trematoda) visualised by confocal microscopy
Comparison of the present findings with those recorded for other digeneans suggests that muscle organisation and innervation patterns in trematodes are highly conserved. Expand
Discovery of multiple neuropeptide families in the phylum Platyhelminthes.
The dataset provides a springboard for investigation of the functional biology and therapeutic potential of neuropeptides in flatworms, simultaneously launching flatworm neurobiology into the post-genomic era. Expand
Neuropeptide-like protein diversity in phylum Nematoda.
The nlp complement of phylum Nematoda is delineates, providing a rich source of neuropeptide ligands for deorphanisation of nematode neuropeptic receptors, and nlp-3, -13, -14, -15 and -18 are amongst the most highly represented transcripts in the dataset. Expand