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Pharmacokinetic interaction of intravenous fentanyl with ketoconazole
Fentanyl is primarily metabolized by CYP3A, but has also been suggested to act as a weak inhibitor of CYP3A. We investigated the influence of CYP3A inhibition by ketoconazole on the pharmacokineticsExpand
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Quantitative low-volume assay for simultaneous determination of fentanyl, norfentanyl, and minor metabolites in human plasma and urine by liquid chromatography—tandem mass spectrometry (LC-MS/MS)
A rapid and sensitive liquid chromatography/tandem mass spectrometric (LC-MS/MS) method for simultaneous quantification of fentanyl (F), norfentanyl (NF), despropionylfentanyl (DPF), andExpand
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Fentanyl Pharmacokinetics is not Dependent on Hepatic Uptake by Organic Anion‐Transporting Polypeptide 1B1 in Human Beings
A recent study investigating the pharmacokinetics of fentanyl in Sprague–Dawley rats suggested fentanyl to be a substrate of rat organic anion‐transporting polypeptide Oatp. In human beings, the mostExpand
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Altersschätzung auf Basis der DNA-Methylierung
ZusammenfassungHintergrundIn Deutschland wird derzeit auch öffentlich eine Diskussion zur „Altersfeststellung“ bei jungen Migranten ohne valide Identitätsdokumente geführt. Dabei wird unter HinweisExpand
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Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study
Several molecular modifications accumulate in the human organism with increasing age. Some of these “molecular clocks” in DNA and in proteins open up promising approaches for the development ofExpand
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Differenzialdiagnose „Zustand nach Hijama“
Im Rahmen von Begutachtungen zu möglichen Folgen von Folterhandlungen fiel mehrfach der Befund gleichartiger Gruppierungen von über den Rücken verteilten, strichförmigen Narben auf. Ein ähnlichExpand
Sudden unexpected cardiac death and postmortem identification of a novel RYR2 gene mutation
A 13-year-old female was found lifeless at home. The autopsy and consecutive histological and toxicological examinations showed blood-rich and edematous lungs and foamy bloody content in the airways.Expand