N. Maffulli

Publications1,983
h-index121
Citations64,748
Highly Influential Citations2,392
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Tendon injury and tendinopathy: healing and repair.
TLDR
There is limited and mixed high-level evidence to support the, albeit common, clinical use of these modalities and further research and scientific evaluation are required before biological solutions become realistic options.
Creatine kinase monitoring in sport medicine.
TLDR
It is probably safe to counsel athletes with suspected myopathy to continue to undertake physical activity at a lower intensity, so as to prevent muscle damage from high intensity exercise and allow ample recovery to favour adequate recovery.
Isokinetic strength and anaerobic power of elite, subelite and amateur French soccer players.
TLDR
It is concluded that hamstring strength is extremely important in soccer players for joint stabilization during various tasks, notably in eccentric action and short-sprinting performance may mirror actual game situations at high level and could be an important determinant of match-winning actions.
Biochemical markers of muscular damage
TLDR
Total antioxidant status can be used to evaluate the level of stress in muscle by other markers, such as thiobarbituric acid-reactive substances, malondialdehyde, sulfhydril groups, reduced glutathione, oxidized glutathion, superoxide dismutase, catalase and others.
The VISA-A questionnaire: a valid and reliable index of the clinical severity of Achilles tendinopathy
TLDR
The VISA-A questionnaire is reliable and displayed construct validity when means were compared in patients with a range of severity of Achilles tendinopathy and control subjects and has the potential to provide utility in both the clinical setting and research.
Sarcopenia: characteristics, mechanisms and functional significance.
TLDR
The causes of the greater anabolic resistance to feeding and exercise of elderly women need elucidating and the enhancement of muscle regeneration via satellite cell activation via the MAPK/notch molecular pathways seems particularly promising.
Biology of tendon injury: healing, modeling and remodeling.
TLDR
The structure of tendons is described, the process of tendon healing is an indivisible process that can be categorized into three overlapping phases for descriptive purposes, and the pathophysiology of tendon injury and healing is reviewed.
The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse
TLDR
Both myofibrillar and tendon protein synthetic rates show progressive decreases during 21 days of disuse; in muscle, this is accompanied by decreased phosphorylation of FAK, with no marked increases in genes for proteolytic enzymes.
Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies
TLDR
It is concluded that study methodology may influence reported surgical outcome and practical guidelines for improving study design are suggested, as improved study design would provide clinicians with a more rigorous evidence‐base for treating patients who have recalcitrant patellar tendinopathy.
How Successful are Current Ankle Replacements?: A Systematic Review of the Literature
TLDR
The overall failure rate was approximately 10% at 5 years with a wide range (range, 0%–32%) between different centers, and ankle function improved after total ankle arthroplasty.
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