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2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Inhibition of angiogenesis is an important new modality for cancer treatment. 2-methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent, currently in clinical trials, whose molecular… Expand
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
- N. Mabjeesh, M. Willard, Carrie E Frederickson, H. Zhong, J. Simons
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 July 2003
PURPOSE Androgen deprivation is implicated in reducing neoangiogenesis in prostate cancer (PCA). Androgens regulate the expression of the vascular endothelial growth factor (VEGF); hypoxia stimulates… Expand
Unusual Alternative Splicing within the Human Kallikrein Genes KLK2 and KLK3 Gives Rise to Novel Prostate-specific Proteins*
- A. David, N. Mabjeesh, +14 authors L. Mintz
- Medicine, Biology
- The Journal of Biological Chemistry
- 17 May 2002
Prostate-specific antigen (PSA) and human kallikrein 2 are closely related products of the human kallikrein genesKLK3 and KLK2, respectively. Both PSA and human kallikrein 2 are produced and secreted… Expand
SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation*
- S. Amir, R. Wang, J. Simons, N. Mabjeesh
- Biology, Medicine
- Journal of Biological Chemistry
- 24 April 2009
A critical mediator of the cellular response to hypoxia is hypoxia-inducible factor 1 (HIF-1). Increased levels of HIF-1α are often associated with increased tumor metastasis, therapeutic resistance,… Expand
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is critically involved in cellular responses to hypoxia, glycolysis, and… Expand
Hypoxia-inducible factor (HIF) in human tumorigenesis.
Hypoxia is a major event that occurs in most solid tumors. Intratumoral hypoxia is sufficient to activate the key transcription factor, hypoxia-inducible factor (HIF) that mediates the activation of… Expand
1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells.
- Moshe Ben-Shoshan, S. Amir, D. Dang, L. Dang, Y. Weisman, N. Mabjeesh
- Molecular cancer therapeutics
In vitro and in vivo studies have shown that 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] inhibits angiogenesis in cancer. We now examined whether the antiangiogenic effects of 1,25(OH)(2)D(3)… Expand
High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound‐guided template saturation biopsy
Study Type – Diagnostic (exploratory cohort)
Clinical efficacy of sildenafil in patients on chronic dialysis.
PURPOSE We evaluate the clinical efficacy of sildenafil citrate for patients who are on chronic dialysis and who have concomitant erectile dysfunction. MATERIALS AND METHODS A total of 35 men (mean… Expand
Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation.
OBJECTIVES To evaluate the efficacy of sildenafil and selective serotonin reuptake inhibitor in alleviating premature ejaculation (PE) in patients in whom other treatments had failed. METHODS… Expand