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Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma
Amplification of 1q21 is the most frequent genetic alteration in human hepatocellular carcinoma (HCC), being detected in 58%‐78% of primary HCC cases by comparative genomic hybridization. Recently,… Expand
COOH-Terminal Truncated HBV X Protein Plays Key Role in Hepatocarcinogenesis
Purpose: X protein (HBx), a product of hepatitis B virus, has been closely associated with the development of hepatocellular carcinoma (HCC). Based on observations that the COOH-terminal truncated… Expand
Oncogenic Role of eIF-5A2 in the Development of Ovarian Cancer
Amplification of 3q26 is one of the most frequent chromosomal alterations in many solid tumors, including ovarian, lung, esophageal, prostate, breast, and nasopharyngeal cancers. A candidate oncogene… Expand
Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma.
Our previous study has suggested an oncogenic role of eIF-5A2 in ovarian tumorigenesis. Abnormalities of eIF-5A2, however, in colorectal carcinoma are unclear. In this study, amplification and… Expand
17β‐Oestradiol enhances the expansion and activation of myeloid‐derived suppressor cells via signal transducer and activator of transcription (STAT)−3 signalling in human pregnancy
- T. Pan, L. Zhong, +9 authors J. Zhou
- Medicine, Biology
- Clinical and experimental immunology
- 1 March 2016
During a successful pregnancy, the maternal immune system plays a critical role in maintaining immunotolerance towards semi‐allogeneic fetal antigens. Recent studies have indicated that… Expand
Increased expression of annexin I is associated with drug-resistance in nasopharyngeal carcinoma and other solid tumors.
- Betty H Y Chow, D. Chua, +9 authors X. Guan
- Medicine, Biology
- Proteomics. Clinical applications
- 1 June 2009
Adjuvant chemotherapy alongside radiotherapy is one of the effective therapies in nasopharyngeal carcinoma (NPC) treatment. However, the appearance of drug resistance is a major obstacle for… Expand
TRIM65 supports bladder urothelial carcinoma cell aggressiveness by promoting ANXA2 ubiquitination and degradation.
Clinically, most of human urothelial carcinoma of the bladder (UCB)-related deaths result from tumor metastasis, but the underlying molecular mechanisms are largely unknown. Recently, a growing… Expand
Eukaryotic Initiation Factor 5A2 Contributes to the Maintenance of CD133(+) Hepatocellular Carcinoma Cells via the c-Myc/microRNA-29b Axis.
Cancer stem cells (CSCs)/cancer-initiating cells (CICs) are suggested responsible for driving cancer resistance to conventional therapies and for cancer recurrence and/or metastasis. CD133 is served… Expand
CHD1L contributes to cisplatin resistance by upregulating the ABCB1–NF-κB axis in human non-small-cell lung cancer
Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a recently identified gene associated with malignant tumor progression and patient chemotherapy resistance in human… Expand
Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival
CHD1L (chromodomain helicase/ATPase DNA binding protein 1-like gene) has been demonstrated as an oncogene in hepatocellular carcinoma (HCC), however, the role of CHD1L in non-small-cell lung cancer… Expand