Skip to search formSkip to main contentSkip to account menu
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
TLDR
It is shown that CDC13 has two discrete roles at the telomere, with the use of two classes of mutations that perturbs a function required in vivo for telomerase regulation but not in vitro for enzyme activity.
View on Publisher
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
TLDR
It is shown that loss of ATRX protein and mutations in the ATRRX gene are hallmarks of ALT–immortalized cell lines, and these attributes will facilitate the diagnosis and treatment ofALT positive human cancers.
View PDF
The structure and function of telomerase reverse transcriptase.
TLDR
The structure and integrity of telomeres are essential for genome stability and regulation by RNA-DNA, TERT- DNA, Tert-RNA, TTERT interactions, and TERN-associated proteins; and the relationship between telomerase enzymology and telomere maintenance is discussed.
View on PubMed
Identification of Functionally Important Domains in the N-Terminal Region of Telomerase Reverse Transcriptase
TLDR
Deletion analysis indicates that even the most N-terminal nonconserved region of yeast TERT (N region) is required for telomerase function, and it is proposed that all TERTs may have a bipartite organization, with an N-GQ domain connected to the other motifs through a flexible linker.
View on ASMUSA
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
TLDR
Structural and functional studies illustrate that, instead of being confined to budding yeast telomeres, the CST complex may represent an evolutionarily conserved RPA-like telomeric complex at the 3' overhangs that works in parallel with or instead of the well-characterized POT1-TPP1/TEBPalpha-beta complex.
View on PubMed
A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator.
TLDR
Purified GRF2 binds to sequences found in many other UASs, in the 35S rRNA enhancer, at centromeres, and at telomeres and combines with a neighboring weak activator to give as much as a 170-fold enhancement.
View on PubMed
Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein
TLDR
The stimulatory effect of GRFI binding sites at UASs for the PYK1 and ENO1 genes is significantly enhanced by flanking DNA elements, which converts this region to a transcriptional silencer.
View on ASMUSA
SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
View on PubMed
Statistical positioning of nucleosomes by specific protein-binding to an upstream activating sequence in yeast.
View on PubMed
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License