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A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition
A better understanding of the regulatory mechanisms related to the EMT can provide a theoretical basis for the early prediction of tumor progression as well as targeted therapy.
Risk Factors for ERCP-Related Complications: A Prospective Multicenter Study
Patient- related factors are as important as procedure-related factors in determining high-risk predictors for post-ERCP overall complications and pancreatitis, however, the risk factors for asymptomatic hyperamylasemia may be mostly procedure related.
Fifth Chinese National Consensus Report on the management of Helicobacter pylori infection
Since the ‘Fourth Chinese National Consensus Report on the management of H. pylori infection’ was published in 2012, three important consensuses (Kyoto global consensus report on H.pylori gastritis, The Toronto Consensus for the Treatment ofH. pylonori infection and the Maastricht V/Florence Consensus report) have been published regarding the management.
Primary Antibiotic Resistance of Helicobacter pylori in China
In China, the prevalence of H. pylori primary resistance to clarithromycin, metronidazole, and levofloxacin was high and increased over time, whereas the resistance rates to amoxicillin, tetracycline, and furazolidone were low and stable over time.
All‐trans retinoic acid down‐regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
- A. Bai, N. Lu, Yuan Guo, Zhanju Liu, Jiang Chen, Zhikang Peng
- Biology, MedicineJournal of leukocyte biology
- 1 October 2009
RA down‐regulates colon inflammatory responses in patients with IBD in vitro and in murine colitis in vivo, representing a potential therapeutic approach in IBD treatment.
Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling
Data suggest extracellular ATP participates in regulation of inflammatory responses of experimental colitis, through P2 × 7 receptor and inflammasome and NFκB signaling, which provides potential alternatives to the current clinical approaches to suppress extrace cellular ATP-mediated immune responsiveness.
Fourth Chinese National Consensus Report on the management of Helicobacter pylori infection
A Delphi method was adopted to develop the consensus of relevant statements and the initial statements were discussed face to face and revised in the conference item by item on 16 December 2016.
Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance
Novel regimens, e.g., vonoprazan-containing triple therapies, quintuple therapies, high-dose dual therapies, and standard triple therapies with probiotics, require further studies concerning their efficiency and safety for treating H. pylori.
Review: Clinical Management of Helicobacter pylori Infection in China
There is no advantage of sequential therapy over triple therapy in Chinese patients, but the efficacy of concomitant therapy must be studied further, and bismuth quadruple therapy could be recommended both as an initial and as a rescue therapy in China.
Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis
It is shown that parasite infection acts through host type 2 immunity to reduce intestinal SFB and expression of IL-17, providing an example of a microbiota-dependent immune modulation by parasites.