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Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus
- N. Lozovaya, Sergei E. Grebenyuk, T. Tsintsadze, Bihua Feng, D. Monaghan, O. Krishtal
- BiologyThe Journal of physiology
- 1 July 2004
Long‐term potentiation (LTP) induced by successive rounds of burst stimulation is accompanied by a long‐term increase in the contribution of extrasynaptic receptors in the afterburst EPSCNMDA.
N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat…
- B. Costa, Bihua Feng, D. Monaghan
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 2009
Consistent with a physiological role for NR2D-containing receptors in the hippocampus, UBP141 displayed greater selectivity than PPDA for inhibiting the slow-decaying component of the NMDA receptor-mediated CA3-CA1 synaptic response in rat hippocampal slices.
Possible functional role of diadenosine polyphosphates: Negative feedback for excitation in hippocampus
Latent N-methyl-D-aspartate receptors in the recurrent excitatory pathway between hippocampal CA1 pyramidal neurons: Ca(2+)-dependent activation by blocking A1 adenosine receptors.
- A. Klishin, T. Tsintsadze, N. Lozovaya, O. Krishtal
- BiologyProceedings of the National Academy of Sciences…
- 19 December 1995
The existence of a powerful system of NMDA receptor-mediated synaptic contacts in SCC input to hippocampal CA1 pyramidal neurons and probably also in reciprocal connections between these neurons, which in the usual preparation are kept latent by activity of A1 receptors are indicated.
A1 adenosine receptors differentially regulate the N-methyl-d-aspartate and non-N-methyl-d-aspartate receptor-mediated components of hippocampal excitatory postsynaptic current in a…
The agonists for nociceptors are ubiquitous, but the modulators are specific: P2X receptors in the sensory neurons are modulated by cannabinoids
Data indicate that cannabinoids may inhibit nociceptive responses produced by P2X receptors, and both endogenous and synthetic cannabinoids (anandamide, WIN55,212-2, and (R)-(+)-methan andamide) inhibit the slow response to ATP mediated by P 2X2 and P2x2/3 receptors in a majority of tested neurons.
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density
Intracellular ATP modifies the voltage dependence of the fast transient outward K+ current in Lymnaea stagnalis neurones.
The data indicate that a change in intracellular ATP concentration modulates the A‐current voltage dependence, which is probably the result of phosphorylation of a channel protein or some associated proteins, but lowering of free Mg2+ concentration cannot be excluded.
N-Methyl-D-aspartate ( NMDA ) Receptor NR 2 Subunit Selectivity of a Series of Novel Piperazine-2 , 3-dicarboxylate Derivatives : Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat…
Sild analysis indicates that these two compounds are competitive glutamate binding site antagonists, and UBP141 and its 9-brominated homolog (UBP145) both display a 7to 10fold selectivity for NR2D-containing receptors over NR2Bor NR2Acontaining receptors.