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Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.
BACKGROUND & AIMS SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transformingExpand
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Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro
Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells (MSC) enteredExpand
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Simultaneous Correlative Scanning Electron and High-NA Fluorescence Microscopy
Correlative light and electron microscopy (CLEM) is a unique method for investigating biological structure-function relations. With CLEM protein distributions visualized in fluorescence can be mappedExpand
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Integration of a high‐NA light microscope in a scanning electron microscope
We present an integrated light‐electron microscope in which an inverted high‐NA objective lens is positioned inside a scanning electron microscope (SEM). The SEM objective lens and the lightExpand
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EB1 and EB3 regulate microtubule minus end organization and Golgi morphology
End-binding proteins (EBs) are the core components of microtubule plus end tracking protein complexes, but it is currently unknown whether they are essential for mammalian microtubule organization.Expand
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The 2018 correlative microscopy techniques roadmap
Abstract Developments in microscopy have been instrumental to progress in the life sciences, and many new techniques have been introduced and led to new discoveries throughout the last century. AExpand
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Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions
Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and cytokinesis. Yet, the molecular machineries that drive endocytic recycling remain largelyExpand
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Single organelle dynamics linked to 3D structure by correlative live‐cell imaging and 3D electron microscopy
Live‐cell correlative light‐electron microscopy (live‐cell‐CLEM) integrates live movies with the corresponding electron microscopy (EM) image, but a major challenge is to relate the dynamicExpand
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Electron Microscopy of Living Cells During in Situ Fluorescence Microscopy.
We present an approach toward dynamic nanoimaging: live fluorescence of cells encapsulated in a bionanoreactor is complemented with in situ scanning electron microscopy (SEM) on an integratedExpand
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Integrated light and scanning electron microscopy of GFP-expressing cells.
Integration of light and electron microscopes provides imaging tools in which fluorescent proteins can be localized to cellular structures with a high level of precision. However, until recently,Expand
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