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Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E
- L. C. Cursino, N. Lima, R. Murillo, C. Nunez, I. Merfort, M. Humar
- Chemistry, BiologyMolecules
- 1 February 2016
Only the chalcone 4 and the flavanone 7 significantly induced lactate dehydrogenase (LDH) release, which was accompanied by activation of caspase-3 and impairment of energy homeostasis in the MTT assay and may explain the killing effect on fish.
Cecropia hololeuca: A new source of compounds with potential anti-inflammatory action
The C. hololeuca bark extract showed important antioxidant and anti-inflammatory activity, emphasizing the industrial and pharmacological potential of this plant.
Inga edulis fruits: a new source of bioactive anthocyanins
The results indicated that even the anthocyanin and derivatized compounds having high antioxidant potential showed an SPF lower than six, which is lower than the minimum accepted by current Brazilian legislation.
Dereplication of terpenes and phenolic compounds from Inga edulis extracts using HPLC-SPE-TT, RP-HPLC-PDA and NMR spectroscopy
The metabolic profile of the species indicated the presence of phenolic compounds as major constituents justifying its strong antioxidant potential performed in β-carotene test.
Chemical profile and biological activities of Deguelia duckeana A.M.G. Azevedo (Fabaceae)
The phytochemical analysis of crude extracts showed the presence of flavonoids and related compounds as major constituents as well as steroids in all of them, and tannins in polar extracts.
Antifungal activity of extracts and phenolic compounds from Deguelia duckeana
Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study
The study demonstrated that the treatment of knee OA with C. longa or M. albicans positively interferes with patients pain and functionality, decreased WOMAC and VASP scores, leading to functional improvement of these patients.
Design, synthesis, and antitumor evaluation of novel anthraquinone derivatives
- Larissa A. Oliveira, H. Nicolella, M. V. Almeida
- Chemistry, BiologyMedicinal Chemistry Research
- 18 June 2020
Results indicated promising candidates for antineoplastic agents for the cancers evaluated, since these compounds showed significant selectivity and high cytotoxic potential for cancer cells, rather than mitoxantrone, the compound of which is already used in anticancer therapy.
Hydroalcoholic extract of Caryocar brasiliense Cambess. leaves affect the development of Aedes aegypti mosquitoes
- Hevilem Letícia Moura do Nascimento Morais, T. Feitosa, G. S. Miranda
- MedicineRevista da Sociedade Brasileira de Medicina…
- 11 September 2020
It is demonstrated that the inhibition of mosquito development by the hydroalcoholic extract of C. brasiliense leaves is demonstrated and substances that may act as active principles are suggested.
Ethnobotanical assessment in protected area from Brazilian Atlantic Forest
In the present study, we conducted a survey on ethnobotanical information of chemical-pharmacological interest, which was acquired via on-site interviews using semi-structured questionnaires with…