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Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
It is shown that inactivation of genes related to RNAi pathway genes, a homolog of Drosophila Dicer (dcr-1), and two homologs of rde-1 (alg-1 and alg-2), cause heterochronic phenotypes similar to lin-4 and let-7 mutations. Expand
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
microRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate the expression of a large fraction of all animal genes and are important in a wide range ofExpand
High-Quality Binary Protein Interaction Map of the Yeast Interactome Network
A comparative quality assessment of current yeast interactome data sets is carried out, demonstrating that high-throughput yeast two-hybrid (Y2H) screening provides high-quality binary interaction information. Expand
The Rice Tapetum Degeneration Retardation Gene Is Required for Tapetum Degradation and Anther Development[W]
Results indicate that TDR is a key component of the molecular network regulating rice tapetum development and degeneration, and two genes, Os CP1 and Os c6, encoding a Cys protease and a protease inhibitor, were shown to be the likely direct targets of TDR. Expand
Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles.
Exposure to TiO(2) NPs could possibly impair the spatial recognition memory ability, and this deficit may be possibly attributed to the disturbance of the homeostasis of trace elements, enzymes and neurotransmitter systems in the mouse brain. Expand
Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity.
It is concluded that TiO(2) nanoparticles injected at the abdominal cavity could be translocated into the brain and in turn caused the brain injury. Expand
Molecular Surveillance of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi by Genotyping and Subtyping Parasites in Wastewater
The distribution of Cryptosporidium species, G. duodenalis genotypes and subtypes, and E. bieneusi genotypes in urban wastewater indicates that anthroponotic transmission appeared to be important in epidemiology of cryptosporidiosis, giardiasis, and microsporidia in the study areas. Expand
Widespread splicing changes in human brain development and aging
Across lifespan, splicing changes followed discrete patterns that could be linked to neural functions, and associated with the expression profiles of the corresponding splicing factors, and were abundant in both of the brain regions studied. Expand
Development of a Multilocus Sequence Typing Tool for High-Resolution Genotyping of Enterocytozoon bieneusi
A multilocus sequence typing tool was developed for high-resolution genotyping of E. bieneusi and produced a genetic relationship that was similar to the one at the ITS locus, with the formation of a large group of zoonotic genotypes that included most E.Bieneusisi genotypes in humans. Expand
Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles.
The results of this study implied that the signaling pathway of liver injury in the TiO(2) NPs-stimulated mouse liver sequentially might occur via activation of TLRs→NIK→IκB kinase→NF-κB→TNF-α→inflammation→apoptosis→liver injury. Expand