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Diabetes in Africa: epidemiology, management and healthcare challenges
TLDR
The total number of people with diabetes in the region is expected to grow because of changing demography, and a concerted multisectoral effort will be critical to ensuring improvement in healthcare delivery.
Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat.
TLDR
It is suggested that glucocorticoid excess in the last trimester of rat pregnancy is sufficient to programme offspring hypertension; also increases basal plasma CORT levels, and permanently attenuates GR and MR mRNA expression in specific hippocampal subfields.
Effect of valsartan on the incidence of diabetes and cardiovascular events.
TLDR
Among patients with impaired glucose tolerance and cardiovascular disease or risk factors, the use of valsartan for 5 years, along with lifestyle modification, led to a relative reduction of 14% in the incidence of diabetes but did not reduce the rate of cardiovascular events.
Guidelines for the treatment and management of new‐onset diabetes after transplantation 1
TLDR
These updated 2004 guidelines, developed in consultation with the International Diabetes Federation, extend the recommendations of the previous guidelines and encompass new‐onset diabetes after kidney, liver and heart transplantation, and are hoped that adoption of these management approaches pre‐ and post‐transplant will reduce individuals’ risk of developing new‐onset diabetes after transplantation.
Effect of nateglinide on the incidence of diabetes and cardiovascular events.
TLDR
Among persons with impaired glucose tolerance and established cardiovascular disease or cardiovascular risk factors, assignment to nateglinide for 5 years did not reduce the incidence of diabetes or the coprimary composite cardiovascular outcomes.
Diabetes in sub-Saharan Africa: from clinical care to health policy.
The Prevalence and Identification of Risk Factors for NIDDM in Urban Africans in Cape Town, South Africa
TLDR
The prevalence of NIDDM in urban Africans in Cape Town, South Africa is moderately high, and considerably higher than previous reports from Africa, and has important implications in view of the large-scale urbanization occurring in southern Africa.
HIV neuropathy in South Africans: Frequency, characteristics, and risk factors
TLDR
The possibility that the incidence of DSP may be reduced with avoidance of stavudine‐containing regimens in older subjects, especially with a history of prior TB infection is raised.
Enabling the genomic revolution in Africa
TLDR
If the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent.
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