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Comparison of the Xpert MTB/RIF Test with an IS6110-TaqMan Real-Time PCR Assay for Direct Detection of Mycobacterium tuberculosis in Respiratory and Nonrespiratory Specimens
TLDR
The Xpert MTB/RIF test is a simple rapid method well adapted to a routine laboratory that appeared to be as sensitive as the IS6110-TaqMan assay with respiratory specimens but less sensitive with paucibacillary specimens, such as smear-negative nonrespiratory specimens. Expand
Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosisand Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA
TLDR
A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncAgene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains, revealing three highly conserved regions in PncA which may play an important role in the processing of pyrazInamide. Expand
Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study
TLDR
It is shown that WGS has a scalable, rapid turnaround, and is a financially feasible method for full MTBC diagnostics, and Continued improvements to mycobacterial processing, bioinformatics, and analysis will improve the accuracy, speed, and scope of WGS-based diagnosis. Expand
Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague.
TLDR
The ability of Y. pestis to destroy immune cells and remain extracellular in the bubo appears to limit exposure to some but not all innate immune effectors. Expand
Characterization of Gentamicin-Susceptible Strains of Methicillin-Resistant Staphylococcus aureus Involved in Nosocomial Spread
TLDR
An outbreak of epidemic Staphylococcus aureusstrains characterized by an unusual heterogeneous resistance to methicillin and resistance to tobramycin but susceptibility to gentamicin, contrasting with gentamicIn-resistant homogeneous MRSA (GR-MRSA) that have been endemic in this hospital since the 1970s is reported. Expand
Comparison of the Real-Time PCR Method and the Gen-Probe Amplified Mycobacterium tuberculosis Direct Test for Detection of Mycobacterium tuberculosis in Pulmonary and Nonpulmonary Specimens
TLDR
The overall sensitivities of the real-time PCR method and AMTDII were similar for respiratory and nonrespiratory specimens, however, real- time PCR seemed to be less susceptible to amplification inhibitors than AMTD II. Expand
Yersinia pestis YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for Virulence in a Rat Model of Bubonic Plague
TLDR
YopJ is not essential for bubonic plague pathogenesis, even after peripheral inoculation of low doses of Y. pestis, and the effects of YopJ appear to overlap and augment the immunomodulatory effects of other Y. weedis virulence factors. Expand
Rapid emergence of Mycobacterium tuberculosis bedaquiline resistance: lessons to avoid repeating past errors
TLDR
Despite its introduction in France in 2011 for XDR- and MDR-tuberculosis treatment, it is reported herein four BDQ-resistant cases, and strategies to avoid a surge of BDQ resistance are discussed. Expand
Drug design from the cryptic inhibitor envelope
TLDR
It is shown by nuclear magnetic resonance spectroscopy that inhibitors of LpxC—an essential enzyme of the lipid A biosynthetic pathway in Gram-negative bacteria and a validated novel antibiotic target—access alternative, minor population states in solution in addition to the ligand conformation observed in crystal structures. Expand
New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague
TLDR
The results suggest that (i) intracellular survival during the early stage of infection is important for plague and (ii) horizontal gene transfer was crucial in the acquisition of this ability. Expand
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