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Characterization of New Mutations in Pyrazinamide-Resistant Strains of Mycobacterium tuberculosisand Identification of Conserved Regions Important for the Catalytic Activity of the Pyrazinamidase PncA
ABSTRACT A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncAgene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. AlignmentExpand
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Comparison of the Xpert MTB/RIF Test with an IS6110-TaqMan Real-Time PCR Assay for Direct Detection of Mycobacterium tuberculosis in Respiratory and Nonrespiratory Specimens
ABSTRACT The sensitivities of the Xpert MTB/RIF test and an in-house IS6110-based real-time PCR using TaqMan probes (IS6110-TaqMan assay) for the detection of Mycobacterium tuberculosis complexExpand
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Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study
Summary Background Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome sequencing (WGS) couldExpand
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Characterization of Gentamicin-Susceptible Strains of Methicillin-Resistant Staphylococcus aureus Involved in Nosocomial Spread
ABSTRACT We report an outbreak of epidemic Staphylococcus aureusstrains characterized by an unusual heterogeneous resistance to methicillin and resistance to tobramycin but susceptibility toExpand
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Comparison of the Real-Time PCR Method and the Gen-Probe Amplified Mycobacterium tuberculosis Direct Test for Detection of Mycobacterium tuberculosis in Pulmonary and Nonpulmonary Specimens
ABSTRACT Real-time PCR was compared to Amplified Mycobacterium tuberculosis Direct Test (AMTDII) for 100 clinical specimens. The overall sensitivities of the real-time PCR method and AMTDII wereExpand
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Rapid emergence of Mycobacterium tuberculosis bedaquiline resistance: lessons to avoid repeating past errors
Bedaquiline (BDQ) has demonstrated potent clinical activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis complex strains [1–3]. It has now beenExpand
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Drug design from the cryptic inhibitor envelope
Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, suchExpand
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Performances of VITEK 2 Colorimetric Cards for Identification of Gram-Positive and Gram-Negative Bacteria
ABSTRACT The purpose of this study was to evaluate the new VITEK 2 identification cards that use colorimetric reading to identify gram-positive and gram-negative bacteria (GP and GN cards,Expand
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First Case of Cerebral Abscess Due to a Novel Nocardia Species in an Immunocompromised Patient
ABSTRACT We report the first case of cerebral abscess due to a novel species of Nocardia in a heart transplant patient and describe the antimicrobial susceptibility of this isolate. As our patientExpand
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Gentamicin-susceptible or gentamicin-resistant methicillin-resistant Staphylococcus aureus: a case-case study.
Gentamicin-susceptible methicillin-resistant Staphylococcus aureus (GS-MRSA) strains are replacing gentamicin-resistant MRSA (GR-MRSA) strains. We showed that exposure to other patients harboringExpand
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