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Summary of the report of the Ad Hoc Task Force on Psychopharmacology of the American Psychological Association.
The American Psychological Association Board of Directors established an ad hoc task force on psychopharmacology to explore the desirability and feasibility of psychopharmacology prescription… Expand
Two dissociable components of behavioral sensitization following repeated amphetamine administration
The acute administration of moderate to high doses (>2 mg/kg) of amphetamine (AMPH) to rats produces a multiphasic behavioral response consisting of an initial period of locomotor activity followed… Expand
Amphetamine and the reward system: Evidence for tolerance and post-drug depression
Existing reports of tolerance to the behavioral effects of d-amphetamine are most parsimoniously interpreted as reflecting behavioral adaptation to the disruptive effects of the drug rather than… Expand
Effects of chronic amphetamine or reserpine on self-stimulation responding: Animal model of depression?
The mood-altering properties of amphetamine (AMPH) in humans (euphoria and depression) have been postulated to be related to the increases and decreases respectively which this drug produces in the… Expand
Tolerance to amphetamine's facilitation of self-stimulation responding: Anatomical specificity
Further work on the phenomenon reported by Leith and Barrett, wherein tolerance was shown to develop to the well-known D-amphetamine-induced facilitation of self-stimulation, clearly indicates that… Expand
Striatal dopamine metabolism in response to apomorphine: the effects of repeated amphetamine pretreatment
The dose-dependent decrease in striatal dopamine (DA) metabolites following apomorphine (APO) administration was utilized as an index of changes in DA receptor sensitivity following the repeated… Expand
Effects of amphetamine, methylphenidate, and apomorphine on regional brain serotonin and 5-hydroxyindole acetic acid
Electrophysiological and cytofluorometric data suggest that doses of amphetamine which enhance locomotor activity and promote focused stereotypies produce pronounced effects on serotonin pathways in… Expand
Clinical Drug Trials in Alzheimer Disease What are Some of the Issues?
Clinical drug trials in Alzheimer disease are underway in many locations throughout the world. That experience has uncovered a number of unique difficulties. In response, members of the Alzheimer's… Expand
The noradrenaline receptor coupled adenylate cyclase system in brain. Lack of modification by changes in the availability of serotonin.
- R. Mishra, N. Leith, L. Steranka, F. Sulser
- Medicine, Chemistry
- Naunyn-Schmiedeberg's archives of pharmacology
The present studies were undertaken to ascertain whether or not an alteration in the availability of serotonin (5HT) can modify central noradrenergic function at the level of the noradrenaline (NA)… Expand
A behavioral and pharmacological analysis or variables mediating active avoidance behavior in rats.