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Early and Severe Hyperparathyroidism Associated with Hypercalcemia After Renal Transplant Treated with Cinacalcet
TLDR
This paper describes the clinical course and biochemical changes in 10 renal transplant recipients with hypercalcemia and severe HPT early after renal transplantation treated with cinacalcet, a calcium mimetic agent, and concludes that correction of HPT was not permanent as discontinuing cinafiltration therapy led to a rapid rise in PTH level. Expand
Combination of peritubular c4d and transplant glomerulopathy predicts late renal allograft failure.
TLDR
In long-term renal allografts, peritubular capillary staining for C4d occurs in approximately 25% of biopsies, can persist for many years after transplantation, and strongly predicts graft loss when combined with transplant glomerulopathy. Expand
Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients.
TLDR
Treatment with leflunomide seemed to be associated with a new toxicity, hemolysis, seen in four of the 27 patients so treated, and a possible association of leflinomide with thrombotic microangiopathy, especially at higher levels was described. Expand
Racial Differences in Determinants of Live Donor Kidney Transplantation in the United States
TLDR
Determinants of racial‐ethnic differences in LDKT among 208 736 patients who initiated treatment for end‐stage kidney disease during 2005–2008 were compared to estimate differences inLDKT attributable to sociodemographic and clinical factors. Expand
Randomized prospective trial of early steroid withdrawal compared with low-dose steroids in renal transplant recipients using serial protocol biopsies to assess efficacy and safety.
TLDR
The immunosuppressive combination of rALG, TAC, and MMF prevents subclinical rejection and the need for high doses of steroids after transplantation, however, continual low-dose steroid therapy may aid in preventing chronic allograft fibrosis. Expand
High levels of dd‐cfDNA identify patients with TCMR 1A and borderline allograft rejection at elevated risk of graft injury
TLDR
The use of dd‐cfDNA may complement the Banff classification and to risk stratify patients with borderline/TCMR 1A identified on biopsy, and is an important molecular marker of active graft injury. Expand
Sex differences in cyclosporine pharmacokinetics and ABCB1 gene expression in mononuclear blood cells in African American and Caucasian renal transplant recipients
TLDR
Female RTR had slower cyclosporine clearance and lower ABCB1 gene expression in PBMC suggesting reduced efflux activity and greater intracellular drug exposure. Expand
Plasma C4d+ Endothelial Microvesicles Increase in Acute Antibody-Mediated Rejection
TLDR
Quantification of plasma C4d+ microvesicles provides information about presence of AMR, its severity and response to treatment in transplant patients and correlated with AMR biopsy severity. Expand
Conversion to low-dose tacrolimus or rapamycin 3 months after kidney transplantation: a prospective, protocol biopsy-guided study.
TLDR
In a low-risk population defined as having a normal 3-month protocol biopsy, TAC levels can be successfully decreased to very low concentrations, and one-year graft function and histology were equally well maintained with either low-dose TAC or SRL immunosuppression. Expand
Donor-Recipient Size Matching Influences Early But Not Late Graft Function After Pediatric En-Bloc Kidney Transplantation
TLDR
It is concluded that donor or recipient size matching up to a recipient-to-donor weight ratio of 7.5 does not significantly impact later renal function after pediatric en-bloc kidney transplantation into adults. Expand
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