• Publications
  • Influence
The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To define the specificExpand
  • 591
  • 51
RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory signaling. RIPK1 alsoExpand
  • 331
  • 19
Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2
ABSTRACT Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that induces cancer cell death by apoptosis with some selectivity. TRAIL-induced apoptosisExpand
  • 277
  • 15
  • PDF
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating mouse Sharpin cpdm mutation causesExpand
  • 154
  • 12
  • PDF
dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIRExpand
  • 122
  • 9
TRAIL in cancer therapy: present and future challenges
Since its identification in 1995, TNF-Related apoptosis-inducing ligand (TRAIL) has sparked growing interest in oncology due to its reported ability to selectively trigger cancer cell death. InExpand
  • 127
  • 7
  • PDF
TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT
Background TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightlyExpand
  • 63
  • 6
The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in aExpand
  • 50
  • 6
  • PDF
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis. Giving leukemia a SMAC Second mitochondria-derived activator of caspases, or SMAC, is a proteinExpand
  • 80
  • 5
Dynamics of HPV16 DNA load reflect the natural history of cervical HPV-associated lesions.
BACKGROUND High burden of high risk human papillomavirus (HR HPV) has been shown to be predictive for the development of high grade cervical lesions and invasive cancers. However, low viral loadExpand
  • 70
  • 5