N. Kyrpides

Publications893
h-index99
Citations61,481
Highly Influential Citations2,689
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Structure, Function and Diversity of the Healthy Human Microbiome
TLDR
The Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far, finding the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals.
Insights into the phylogeny and coding potential of microbial dark matter
TLDR
This study applies single-cell genomics to target and sequence 201 archaeal and bacterial cells from nine diverse habitats belonging to 29 major mostly uncharted branches of the tree of life and provides a systematic step towards a better understanding of biological evolution on the authors' planet.
IMG: the integrated microbial genomes database and comparative analysis system
TLDR
The Integrated Microbial Genomes system serves as a community resource for comparative analysis of publicly available genomes in a comprehensive integrated context and provides tools and viewers for analyzing and reviewing the annotations of genes and genomes inA comparative context.
Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite
TLDR
A metagenomic analysis of the bacterial community resident in the hindgut paunch of a wood-feeding ‘higher’ Nasutitermes species shows the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis, the first system-wide gene analysis of a microbial community specialized towards plant lignocellulose degradation.
Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis
TLDR
The sequencing and analysis of the type strain B. cereus ATCC 14579 together with the gapped genome of B. anthracis A2012 enables the comparative analysis to clarify the phylogeny of the cereus group, and the latter to determine plasmid-independent species-specific markers.
Metagenomic analysis of two enhanced biological phosphorus removal (EBPR) sludge communities
TLDR
A metagenomic analysis of two lab-scale EBPR sludges dominated by the uncultured bacterium, “Candidatus Accumulibacter phosphatis,” sheds light on several controversies in EBPR metabolic models and provides hypotheses explaining the dominance of A. phosphatis.
The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode
TLDR
Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosYmbionT evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease.
CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats
TLDR
A new tool is introduced that rapidly and accurately identifies CRISPRs in large DNA strings, such as genomes and metagenomes, using a simple sequential scan of a DNA sequence and detects repeats directly without any major conversion or preprocessing of the input.
The genomic basis of trophic strategy in marine bacteria
TLDR
This work compares the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis RB2256, that serve as useful model organisms for copiotrophic and oligotrophic modes of life and relates the genomic features to trophic strategy for these organisms and defines their molecular mechanisms of adaptation.
Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000.
TLDR
The genomic comparison suggests that several unique genes for Pss B728a such as ectoine synthase, DNA repair, and antibiotic production may contribute to the epiphytic fitness and stress tolerance of this organism.
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