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Gastroprotection by pentoxyfilline against stress-induced gastric damage. Role of lipid peroxidation, antioxidizing enzymes and proinflammatory cytokines.
TLDR
PTX exerts beneficial, gastroprotective effect against WRS-induced gastric lesions due to enhancement in gastric microcirculation, possibly mediated by the enhanced NOS activity as well as local action of NO and by the attenuation of oxidative metabolism and generation proinflammatory cytokines. Expand
Cholecystokinin receptors and vagal nerves in control of food intake in rats.
TLDR
This study was designed to determine the specificity and physiological nature of short-term satiety effects of cholecystokinin in rats with intact and transected vagal nerves and found only bombesin reduced food intake, whereas gastrin, secretin, gastric inhibitory polypeptide (GIP), pancreatic polypeptin (PP), and peptide YY (PYY) were ineffective. Expand
Comparison of intraduodenal and intravenous administration of amino acids on gastric secretion in healthy subjects and patients with duodenal ulcer.
TLDR
It is indicated that amino acids are capable of stimulating gastric secretion after intraduodenal and after intravenous administration and is strongly suppressed by histamine H2-blocker. Expand
Inhibition of gastric secretion by fat and hypertonic glucose in the dog: role of gastric inhibitory peptide.
TLDR
It is concluded that GIP is unlikely to mediate fat‐induced inhibition of gastric secretion, but it is still possible that it might be involved in the inhibition that occurs during intestinal perfusion with hypertonic glucose solutions. Expand
The role of reactive oxygen species and capsaicin-sensitive sensory nerves in the pathomechanisms of gastric ulcers induced by stress.
TLDR
It is demonstrated that inactivation of sensory nerves resulted in magnification of gastric mucosal damage induced by the WRS, and oxidative stress, as reflected by an increase of MDA and 4-HNE tissue concentrations (an index of lipid peroxidation), as well as decrease of SOD activity, could play an important role. Expand
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC).
TLDR
It is indicated that the deficiency of endogenous PGs may play a role in the pathogenesis ulcer and that the degree of gastric mucosal damage by NOSAC is closely related to the alteration in the capability of the mucosa to generate PGs. Expand
Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats
TLDR
In conscious cats with gastric fistulae and the diversion of bile and pancreatic juice to jejunum, secretin, CCK, and jejunal acidification prevented the formation of duodenal ulcerations in conscious cats infused with pentagastrin or histamine for 36 hours. Expand
Comparison of methylated prostaglandin E2 analogues given orally in the inhibition of gastric responses to pentagastrin and peptone meal in man.
TLDR
These methylated PG analogues are very potent inhibitors of gastric acid and pepsin secretion stimulated by pentagastrin or a meal and may have clinical potential in the treatment of peptic ulcer. Expand
Double blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man.
TLDR
It is concluded that sucralfate has a potent protective action on spontaneous and aspirin treated gastric microbleeding in man and that this protection may be partly because of the increased mucosal biosynthesis of prostaglandins. Expand
Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.
TLDR
It is confirmed that oral PGE2 has a protective action on gastric mucosa exposed to aspirin and that this property is also shared by ranitidine, a potent histamine H2-receptor antagonist. Expand
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