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An endothelial receptor for oxidized low-density lipoprotein
The molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells is reported, which is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs. Expand
Molecular Cloning of a Novel Scavenger Receptor for Oxidized Low Density Lipoprotein, SR-PSOX, on Macrophages*
A novel class of molecule belonging to the scavenger receptor family, which may play important roles in pathophysiology including atherogenesis, is isolated from a cDNA library of phorbol 12-myristate 13-acetate-stimulated THP-1 cells. Expand
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells.
It is concluded that lyso-PC can selectively induce VCAM-1 and IC AM-1 in arterial endothelial cells and that this action, in addition to its monocyte chemoattractant activity, may play an important role in monocyte recruitment into atherosclerotic lesions. Expand
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
LOX-1 may play important roles in Ox-LDL uptake and subsequent functional alteration in the luminal endothelium in early atherosclerotic lesions and in intimal neovascular endothelial cells in advanced plaques. Expand
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
It is shown that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis and a novel interaction between SRE BP-1 and SREBP-2 mediated by miR -33 in vivo is elucidated. Expand
Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration
Findings suggest that oxidative stress is involved in the pathogenesis of AMD possibly by oxidizing phospholipids in the photoreceptors as demonstrated in the arterial intima of patients with atherosclerosis. Expand
MicroRNA-33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE−/− Mice
It is demonstrated that miR-33 deficiency serves to raise HDL-C, increase cholesterol efflux from macrophages via ABCA1 and ABCG1, and prevent the progression of atherosclerosis. Expand
Cell surface‐anchored SR‐PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6‐expressing cells
SR‐PSOX/CXCL16 is a unique molecule that not only attracts T cells and NKT cells toward DCs but also supports their firm adhesion to DCs. Expand
[Oxidized LDL].
  • N. Kume
  • Medicine
  • Nihon rinsho. Japanese journal of clinical…
  • 2001
Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Elevated in Acute Coronary Syndrome: A Novel Marker for Early Diagnosis
Serum sLOX-1 levels were significantly higher in ACS than the other groups and were associated with ACS as shown by multivariable logistic regression analyses and peak values of s LOX- 1 in ACS were observed earlier than those of TnT. Expand