Carotenoid actions and their relation to health and disease.
Dietary modification of human macular pigment density.
- B. Hammond, E. Johnson, D. Snodderly
- MedicineInvestigative Ophthalmology and Visual Science
- 1 August 1997
When MP density increased with dietary modification, it remained elevated for at least several months after resuming an unmodified diet and appears to be feasible for many persons.
Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.
Although increasing the intake of lutein or zeaxanthin might prove to be protective against the development of age-related macular degeneration, a causative relationship has yet to be experimentally demonstrated.
Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke.
- X. D. Wang, C. Liu, R. Bronson, D. Smith, N. Krinsky, M. Russell
- Medicine, BiologyJournal of the National Cancer Institute
- 6 January 1999
Diminished retinoid signaling, resulting from the suppression of RARbeta gene expression and overexpression of activator protein-1, could be a mechanism to enhance lung tumorigenesis after high-dose beta-carotene supplementation and exposure to tobacco smoke.
The Biochemical Characterization of Ferret Carotene-9′, 10′-Monooxygenase Catalyzing Cleavage of Carotenoids in Vitro and in Vivo*
- K. Hu, Chun Liu, H. Ernst, N. Krinsky, R. Russell, Xiang‐Dong Wang
- Chemistry, BiologyJournal of Biological Chemistry
- 1 March 2006
It is demonstrated that the recombinant ferret CMO2 catalyzes the excentric cleavage of both all-trans-β-carotene and the 5-cis- and 13- cis-isomers of lycopene at the 9′,10′-double bond but not all- trans-lycopene.
Antioxidant functions of carotenoids.
- N. Krinsky
- BiologyFree Radical Biology & Medicine
Sex Differences in Macular Pigment Optical Density: Relation to Plasma Carotenoid Concentrations and Dietary Patterns
Mechanism of Action of Biological Antioxidants
- N. Krinsky
- BiologyProceedings of the Society for Experimental…
- 1 June 1992
It becomes increasingly important to understand which compounds can function as antioxidants, where they are located in the body, and what their mechanism of action might be.
Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables.
Most of the measurableCarotenoids of human plasma can be increased by moderate alterations in diet within a short time, although the magnitude of the plasma response may be related to the baseline carotenoid concentrations.