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Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure.
Data indicate that PTH-7-84 antagonizes PTH-(1-84) effect not only on serum calcium but also on osteoblasts to affect bone turnover, and radioligand binding experiments demonstrate that P TH-(7-1984) binds specifically to SaOS cells and is equally displaced by both PTH and (7- 84), but only partially displaced by PTH-[1-34]. Expand
Parathyroid Hormone/Parathyroid Hormone‐Related Peptide Type 1 Receptor in Human Bone
The results provide the novel evidence of PTH‐1R in human osteoclasts and suggest a functional role for the receptors in 2°HPT. Expand
Vitamin D4 in Mushrooms
Vitamin D4 should be expected to occur in mushrooms exposed to UV light, such as commercially produced vitamin D enhanced products, wild grown mushrooms or other mushrooms receiving incidental exposure, and researchers analyzing vitamin D2 in mushrooms and using D3 as an internal standard should verify that the system will resolve vitamins D3 and D4. Expand
Hormone- and DNA-binding mechanisms of the recombinant human estrogen receptor.
Data indicate that the recombinant hER is valuable to define the biochemical and structural properties of the native estrogen receptor. Expand
Tuberous Sclerosis Gene 2 Product Modulates Transcription Mediated by Steroid Hormone Receptor Family Members*
It is shown that TSC2 protein can bind and selectively modulate transcription mediated by members of the steroid receptor superfamily of genes, which strengthens the expanding body of evidence that these coregulators may play critical roles in cellular differentiation. Expand
Suppression of the Human Parathyroid Hormone Promoter by Vitamin D Involves Displacement of NF-Y Binding to the Vitamin D Response Element*
Findings suggest that the repressive effects of vitamin D on hPTH gene transcription may involve displacement of NF-Y binding to the proximal site by the VDR heterodimer, which subsequently attenuates synergistic transactivation. Expand
Evidence of functional vitamin D receptors in rat hippocampus
These findings clearly document the localization of vitamin D receptor in rat hippocampus and that hippocampus contains vitamin D receptors capable of specifically binding to DNA, and suggest that the endogenous vitamin Dceptor may mitigate processes related to cellular homeostasis, perhaps through a calcium buffering mechanism. Expand
Secondary hyperparathyroidism and vitamin D receptor binding to vitamin D response elements in rats with incipient renal failure.
The pathogenesis of secondary hyperparathyroidism in early renal failure is poorly understood. In the study presented here, parathyroid hormone and GFR in rats with mild renal failure of variousExpand
Retinoic acid receptor gamma 2 interactions with vitamin D response elements
The data highlight the novel ability of RARgamma2 to interact with VDREs and impact vitamin D activity, which would allow for additional fine-tuning of a transcriptional response depending on ligand availability and expression profile of these nuclear receptors in a given cell type. Expand
Estrogen receptor phosphorylation. Hormonal dependence and consequence on specific DNA binding.
The data suggest that transcriptional activation by the estrogen receptor involves an estrogen-dependent phosphorylation of the receptor resulting in its increased affinity for specific DNA sequences. Expand