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Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats.
Combined OTA+FB(1) treatment measured either by the standard comet or the Fpg-modified comet assay showed a synergistic increase in the tail intensity and OTM in kidney cells, even at doses that correspond to the daily human exposure in Europe. Expand
Assessment of genotoxic risks in Croatian health care workers occupationally exposed to cytotoxic drugs: a multi-biomarker approach.
- N. Kopjar, V. Garaj-Vrhovac, +4 authors D. Želježić
- International journal of hygiene and…
- 1 July 2009
Overall results of this study confirmed that handling cytotoxic drugs without appropriate safety precautions involves a potential genotoxic risk for exposed subjects, and cytogenetic surveillance of exposed workers is also recommended. Expand
Evaluation of genome damage and its relation to oxidative stress induced by glyphosate in human lymphocytes in vitro
- M. Mladinić, S. Berend, A. Vrdoljak, N. Kopjar, B. Radić, D. Želježić
- Medicine, Biology
- Environmental and molecular mutagenesis
- 1 December 2009
Since for any of the assays applied, no clear dose‐dependent effect was observed, it indicates that glyphosate in concentrations relevant to human exposure do not pose significant health risk. Expand
Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay.
- V. Benković, A. Knežević, +5 authors N. Kopjar
- Chemistry, Medicine
- Phytomedicine : international journal of…
- 17 October 2008
Positive results obtained on gamma-irradiated mice given EEP and quercetin, complementary with earlier observations on survival of irradiated mice, indicate that these compounds could be considered effective non-toxic radioprotectors. Expand
Evaluation of genotoxic effects of lead in pottery-glaze workers using micronucleus assay, alkaline comet assay and DNA diffusion assay
- V. Kašuba, R. Rozgaj, +5 authors A. Jazbec
- Chemistry, Medicine
- International Archives of Occupational and…
The results indicate a need for concomitant use of at least two different biomarkers of exposure when estimating a genetic risk of lead exposure, and show higher influence of tested parameters to DNA damage. Expand
The alkaline Comet assay as biomarker in assessment of DNA damage in medical personnel occupationally exposed to ionizing radiation.
It was found that medical workers who were occupationally exposed to ionizing radiation for different periods of time showed highly significant increases in levels of DNA damage compared with controls, which confirmed the usefulness of the alkaline Comet assay as an additional complement to standard biodosimetric methods. Expand
Evaluation of DNA damage in white blood cells of healthy human volunteers using the alkaline comet assay and the chromosome aberration test.
Although higher levels of DNA damage were recorded in blood samples collected during winter and autumn, they were mostly influenced by medicinal exposure and smoking habit, and can serve as control values in forthcoming biomonitoring studies. Expand
Alkaline comet assay study with breast cancer patients: evaluation of baseline and chemotherapy-induced DNA damage in non-target cells
- N. Kopjar, I. Milas, V. Garaj-Vrhovac, M. Gamulin
- Biology, Medicine
- Clinical and Experimental Medicine
- 1 December 2006
The present study confirmed the alkaline comet assay as a sensitive technique able to detect significantly elevated DNA migration in blood cells of patients already one hour after completion of the first cycle of chemotherapy. Expand
Effects of low doses of glyphosate on DNA damage, cell proliferation and oxidative stress in the HepG2 cell line
- V. Kašuba, M. Milić, +9 authors D. Želježić
- Medicine, Chemistry
- Environmental Science and Pollution Research
- 30 June 2017
The elevated levels of cytogenetic damage found by the CBMN assay and the mechanisms of primary DNA damage should be further clarified, considering that the comet assay results indicate possible cross-linking or DNA adduct formation. Expand
Assessment of the radioprotective effects of amifostine and melatonin on human lymphocytes irradiated with gamma-rays in vitro.
- N. Kopjar, Slavica Miocić, S. Ramić, M. Milić, T. Viculin
- Chemistry, Medicine
- Arhiv za higijenu rada i toksikologiju
- 3 October 2005
This study shows that it is possible combine these radioprotectors by adjusting the doses of amifostine to achieve the best radioprotsective effect with as few side effects as possible. Expand