Platinum Complexes with Bioactive Nitroxyl Radicals: Synthesis and Antitumor Properties
- V. Sen', A. Terentiev, N. Konovalova
- Biology, Chemistry
- 12 September 2012
Recent studies have shown that simple nitroxyls affect the cell viability through a redox-mediated signaling and induce a multifactor cell death response, including oxidative damage, cell cycle arrest and apoptosis.
[ANTI-TUMOR ACTIVITY OF FREE STABLE RADICALS].
- N. Konovalova, G. N. Bogdanov, V. B. Miller, M. NeÇman, E. G. Rozantsev, N. Emanuel
- ChemistryDoklady Akademii nauk SSSR
- 21 June 1964
[Experimental determination of the antileukemic effect of 1,2-bis-diazoacetylethane].
- N. Emanuel, L. Gumanov, Z. I. Orlova
- ChemistryDoklady Akademii nauk SSSR
- 1 November 1968
Nitric oxide donor increases the efficiency of cytostatic therapy and retards the development of drug resistance.
- N. Konovalova, S. Goncharova, L. M. Volkova, T. Rajewskaya, L. Eremenko, A. Korolev
- Biology, MedicineNitric oxide
- 1 February 2003
Synthesis, structure and biological activity of nitroxide malonate methanofullerenes.
- V. Gubskaya, L. S. Berezhnaya, I. Nuretdinov
- ChemistryOrganic and biomolecular chemistry
- 6 March 2007
For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.
[Paramagnetic diethyleneimides of urethane phosphoric acids as antitumor agents].
- N. Emanuel, R. Zhdanov, N. Konovalova, L. S. Vasil'eva, N. A. Buina
- ChemistryVoprosi onkologii
- 1980
The nitroxyl radical was shown to participate in the antitumor effect manifestation of paramagnetic diethylene imides of urethan phosphoric acids containing three type groups showing carcinostatic activity.
Synthesis and antitumor activity of platinum(II) complexes with trans-3,4-diamino-2,2,6,6-tetramethylpiperidine-1-oxyl.
- V. Sen', V. A. Golubev, L. M. Volkova, N. Konovalova
- ChemistryJournal of Inorganic Biochemistry
- 1 October 1996
Ecdysterone Modulates Antitumor Activity of Cytostatics and Biosynthesis of Macromolecules in Tumor-Bearing Mice
- N. Konovalova, Y. Mitrokhin, L. M. Volkova, L. I. Sidorenko, I. Todorov
- Biology, MedicineBiology Bulletin of the Russian Academy ofâĤ
- 1 November 2002
The influence of therapeutic and half doses of cisplatin and adriamycin combination with the anabolic drug ecdysterone (20-hydroecdison) on development of subcutaneously and intraperitoneallyâĤ
Synthesis and biological activity of a novel water-soluble methano[60]fullerene tetracarboxylic derivative
- A. Kornev, A. Peregudov, P. Troshin
- Chemistry
- 1 November 2013
[Nitroxyl derivatives of rubomycin].
- N. Emanuel, N. Konovalova, R. F. D'iachkovskaia, L. K. Denisova
- Chemistry, MedicineAntibiotiki
- 1 November 1982
It was demonstrated that ruboxyl-l had a lower cardiotoxicity than rubomycin and did not inhibit hemopoiesis at the maximum tolerated doses.
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