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A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
It is suggested that C-CPE enhances the absorption of dextran in rat jejunum, apparently through interactions with claudin-4, and this effect may represent an effective novel strategy for enhancing theabsor of drugs. Expand
CAR- or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice
It is suggested that continued interaction of either the fiber with CAR or the penton base with αv integrin offers an effective route of virus entry into mouse liver in vivo and inhibition of the interaction is likely to be crucial to the development of targeted Ad vectors. Expand
Adenovirus vector-mediated gene transfer into stem cells.
Advances in the development of Ad vectors suitable for stem cells are reviewed and their application in basic biology and clinical medicine is discussed. Expand
A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob
A simple system to construct fiber-modified vectors containing a foreign ligand in the HI loop of the fiber knob is developed and suggested that the mutant virus mediated CAR-independent cell entry pathway is suggested. Expand
Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon
Comparisons of the characterization of Ad vectors containing the FLAG tag (DYKDDDDK) or RGD (CDCRGDCFC) peptide could provide basic information for the generation of capsid-modified Ad vectors. Expand
RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells
The results suggested that the combination of fiber-modified Ad vectors containing polylysine peptides and RNAi is an effective tool for the study of the biological and physiological mechanism of adipogenesis in adiposity and diabetes using 3T3-L1 models. Expand
Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors.
It is shown that serotype 5 human Ad vectors elicit innate immune responses through a myeloid differentiating factor 88 (MyD88)/Toll-like receptor (TLR)-9-dependent and/or -independent manner according to cell type, and suggests that Ad vectors can activate innate immunity via MyD88/TLR9- dependent and -independent mechanisms. Expand
Fiber-Modified Adenovirus Vectors Decrease Liver Toxicity through Reduced IL-6 Production1
This study contributes to an understanding of the biological mechanism in innate immune host responses and liver toxicity toward systemically administered Ad vectors and will help in designing safer gene therapy methods that can reduce robust innate immunity and inflammatory responses. Expand
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity.
The fiber knob mutation is optimized for further reduced in vivo transduction for further improving the mutant Ad vector, abolishing both viral natural tropism and toxicity. Expand
The preparation of a solid dispersion powder of indomethacin with crospovidone using a twin-screw extruder or kneader.
A solid dispersion (SD) powder of indomethacin (IM) with CrosPVP was prepared continuously using a twin-screw extruder (extruder) or twin-screw kneader (kneader), which made it possible toExpand