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Abnormal premovement gating of somatosensory input in writer's cramp.
TLDR
These findings indicate that in writer's cramp the sensitivity of sensory input channels from the hand is wrongly set by the central command to move, and the sensory trick, by supplying additional input not usually present during unobstructed movement, is a manoeuvre to correct this imbalance.
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Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease
TLDR
Long-read sequencing identifies a GGC repeat expansion in NOTCH2NLC that is associated with neuronal intranuclear inclusion disease, a progressive neurodegenerative disorder, and results in abnormal anti-sense transcripts that could contribute to disease pathogenesis.
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Tonic vibration reflex and muscle afferent block in writer's cramp
TLDR
It is suggested that muscles causing dystonic movements have abnormal sensitivities to vibration at rest and that muscle afferents may play a pivotal role in producing dySTONic movements.
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F-wave latency serves as the most reproducible measure in nerve conduction studies of diabetic polyneuropathy: multicentre analysis in healthy subjects and patients with diabetic polyneuropathy
Aims/hypothesis. For use in future drug development for diabetic polyneuropathy, we conducted multicentre trials to assess the reproducibility of nerve conduction studies.¶Methods. All measurements…
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Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke: Phase1/2a Clinical Trial in a Homogeneous Group of Stroke Patients
TLDR
Positive results and trends favoring neurologic recovery and improvement in cerebral blood flow and metabolism by cell therapy underscore the relevance of larger scale randomized controlled trials using this approach.
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Abnormal excitability of the corticospinal pathway in patients with amyotrophic lateral sclerosis: a single motor unit study using transcranial magnetic stimulation.
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Effect of maturation on nerve excitability in an experimental model of threshold electrotonus
TLDR
The findings indicate that mature rats (>400 g) may provide a useful experimental model for interpreting abnormal TE responses in humans, and provide evidence for nonlinear maturation of potassium channel function in myelinated axons.
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Pre-movement gating of short-latency somatosensory evoked potentials.
TLDR
Gating effects were widespread in frontal and central areas, but were also seen, albeit to a lesser extent, in the recordings at P3 (P30).
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Muscle afferent block for the treatment of oromandibular dystonia
TLDR
Diluted lidocaine and alcohol intramuscularly is used for the treatment of drug‐resistant oromandibular dystonia with clinical improvement and reduced EMG activities in the affected muscles, whereas control injection of normal saline gave no changes inEMG activities.
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Activity-dependent conduction block in multifocal motor neuropathy.
TLDR
This study is the first to show that activity-dependent conduction block plays a role in human disease by causing muscle fatigue in patients with multifocal motor neuropathy.
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