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Synthesis of prolyl endopeptidase inhibitors and evaluation of their structure-activity relationships: in vitro inhibition of prolyl endopeptidase from canine brain.
- H. Arai, H. Nishioka, +6 authors Y. Ikeda
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 15 September 1993
By chemical modification of a known prolyl endopeptidase (PEP) inhibitor (N-[N-(4-phenylbutanoyl)-L-prolyl]pyrrolidine; SUAM-1221), several arylalkanoyl derivatives (V-1--27) were synthesized and… Expand
New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues.
New compounds were synthesized by structural modification of 1-[1-(4-phenylbutanoyl)-L-prolyl]-pyrrolidine (SUAM-1221, 1) or 1-[1-(benzyloxycarbonyl)-L-proly]prolinal (Z-Pro-prolinal,2) and were… Expand
New Acylic Diterpene Glycosides, Capsianosides VI, G and H from the Leaves and Stems of Capsicum annuum L.
Capsicum species are very important plants used as vegetable foods, species and external medicines. In the preceding paper, we disclosed the occurrence of novel acylic diterpene glycosides from… Expand
A sensitive detection method for peptide using 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole and its application to measure prolyl endopeptidase activity.
- K. Yoshinaga, N. Kobayashi, Y. Nagatani, Y. Tanaka, Y. Ikeda
- Chemistry, Medicine
- Biomedical chromatography : BMC
- 1 November 1994
A measuring method sensitive to prolyl endopeptidase (EC 188.8.131.52, PEP) activity using native peptides (Arg-vasopressin or substance P) as substrates was established. The investigation of three… Expand
New Potent Prolyl Endopeptidase Inhibitors: Synthesis and Structure‐ Activity Relationships of Indan and Tetralin Derivatives and Their Analogues.
Synthesis of Prolyl Endopeptidase Inhibitors and Evaluation of Their Structure‐Activity Relationships: in vitro Inhibition of Prolyl Endopeptidase from Canine Brain.
PURIFICATION AND CHARACTERIZATION OF PROLYL ENDOPEPTIDASE FROM CANINE BRAIN
A process for preparing an imide derivative of amino-substituted n.
SE DESCUBRE NUEVO AMINO ACIDO DERIVADO DE AMINA, N SUSTITUIDO. LOS COMPUESTOS SON REPRESENTADOS POR FORMULA COMPLEJA CON N REPRESENTANDO UN ENTERO DE 0 A 5, YXEY, LAS CUALES PUEDEN SER LO MISMO O… Expand
Use of 1- [3- (dimethylamino) propyl] -1-phenylphthalenen for treating cerebrovascular disorders.
Studies on the triterpenoid glycosides in Lonicerae Caulis et Folium