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Aims/hypothesisThe islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit… (More)
Aims/hypothesisStudies on the biology of the microvascular endothelial cells (MECs) that surround and penetrate the pancreatic islets are hampered by difficulties in isolating and culturing large… (More)
The basic physiology of leucocyte emigration from the intravascular space into the tissues is now known to be dependent on a class of cell surface molecules that have come to be known as adhesion… (More)
The injury to vascular endothelium seen in severe bacterial infection may be mediated by neutrophil-derived enzymes. Neutrophil adhesion to endothelium, a prerequisite for this process, is mediated… (More)
CD40L is a membrane protein belonging to the tumour necrosis factor family, originally found on activated T cells. The CD40L-CD40 interaction is of critical importance in the adaptive immune… (More)