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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.
The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators ofExpand
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Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation
gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor,Expand
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A Seed for Alzheimer Amyloid in the Brain
A fundamental question about the early pathogenesis of Alzheimer's disease (AD) concerns how toxic aggregates of amyloid β protein (Aβ) are formed from its nontoxic soluble form. We hypothesizedExpand
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A potential function for neuronal exosomes: Sequestering intracerebral amyloid‐β peptide
Elevated amyloid‐β peptide (Aβ) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome‐associated Aβ in the cerebrospinal fluid (CSF) of cynomolgusExpand
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
BackgroundOne of the best-characterized causative factors of Alzheimer’s disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied byExpand
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Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains.
We characterized senile plaques (SPs) immunohistochemically in cynomolgus monkey brains and also examined age-related biochemical changes of Alzheimer's disease (AD)-associated proteins in theseExpand
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Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
We elucidated how Alzheimer-type pathologies of amyloid beta-protein (Abeta) and tau spatiotemporally emerge in brains of nontransgenic nonhuman primate, cynomolgus monkey, in the present study. ToExpand
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Aβ Upregulates and Colocalizes with LGI3 in Cultured Rat Astrocytes
 1. The leucine-rich glioma inactivated (LGI) family of genes encodes a leucine-rich repeat (LRR) protein, proteins that are thought to be specifically involved in protein–protein and protein–matrixExpand
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Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive motoneuron loss. Redistribution of transactive response deoxyribonucleic acid-binding protein 43 fromExpand
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Diabetes Mellitus Induces Alzheimer’s Disease Pathology: Histopathological Evidence from Animal Models
  • N. Kimura
  • Medicine
  • International journal of molecular sciences
  • 1 April 2016
Alzheimer’s disease (AD) is the major causative disease of dementia and is characterized pathologically by the accumulation of senile plaques (SPs) and neurofibrillary tangles (NFTs) in the brain.Expand
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