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The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology
The authors regret the inability to cite all of the primary literature contributing to this review due to length considerations, but wish to thank F. Chan, T. Migone, and J. Wang for insightful comments on the manuscript. Expand
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1
- N. Haynes, Christopher D C Allen, R. Lesley, K. Ansel, N. Killeen, J. Cyster
- Biology, Medicine
- The Journal of Immunology
- 15 October 2007
It is suggested that development and/or maintenance of a PD-1high follicular Th cell subset is dependent on appropriate interaction with GC B cells, and this study finds that transgenic CXCR5 overexpression is not sufficient to promote follicular entry of naive T cells unless the counterbalancing influence of CCR7 ligands is removed. Expand
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.
Migratory CD11b(+) cDCs are identified as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung. Expand
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
It is shown that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division, suggesting a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity. Expand
Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses
In vivo deletion of Gata3 using OX40-Cre eliminated TH2 responses and allowed the development of interferon-γ-producing cells in mice infected with Nippostrongylus brasiliensis, indicating that GATA-3 serves as a principal switch in determining TH1-TH2 responses. Expand
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.
It is shown that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion, and a temporal relationship exists between CD28 and Ox40, with OX 40 being a critical regulator of antigen- driven T cell survival. Expand
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.
- B. Valzasina, C. Guiducci, H. Dislich, N. Killeen, A. Weinberg, M. Colombo
- Biology, Medicine
- 1 April 2005
Results suggest that in addition to controlling memory T-cell numbers, OX40 directly controls T reg-mediated suppression of graft-versus-host disease. Expand
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.
It is shown that conditional deletion of rictor impaired differentiation into T helper 1 and Th2 cells without diversion into FoxP3(+) status or substantial effect on Th17 cell differentiation, and vital mTOR-PKC and m TOR-Akt connections in T cell differentiation are uncovered. Expand
OX40 costimulation turns off Foxp3+ Tregs.
OX40 was dispensable for the genesis and suppressor functions of naturally arising CD4(+)Foxp3(+) Tregs, but stimulating OX40 on the Foxp3 (+) T Regs abrogated their ability to suppress T effector cell proliferation, IFN-gamma production, and T effectors allograft rejection. Expand
Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells1
Although the data reveal important roles for OX40 signaling in Treg cell development, homeostasis, and suppressive activity, they also show that Ox40 signals can oppose Treg-mediated suppression when they are delivered directly to Ag-engaged naive T cells. Expand