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IL-2 Regulates Perforin and Granzyme Gene Expression in CD8+ T Cells Independently of Its Effects on Survival and Proliferation1
TLDR
It is shown that IL-2 increased the expression of perforin and granzyme A, B, and C mRNA; intracellular granzyme B protein levels; and cytolytic function in a dose-dependent manner during primary activation of murine CD8+ T cells in vitro.
A Clonal Culture System Demonstrates That IL-4 Induces a Subpopulation of Noncytolytic T Cells with Low CD8, Perforin, and Granzyme Expression1
TLDR
It is concluded that IL-4 promotes the development of a noncytolytic CD8low T cell phenotype that might be important in tumor- or pathogen-induced immune deviation.
Progressive Differentiation and Commitment of CD8+ T Cells to a Poorly Cytolytic CD8low Phenotype in the Presence of IL-41
TLDR
It is concluded that IL-4-dependent down-regulation of CD8 is associated with progressive differentiation and commitment to yield IL- 4-producing cells with little cytolytic activity, suggesting that the CD4−CD8− cells identified in some disease states may be the product of a previously unrecognized pathway of effector differentiation from conventional CD8+ T cells.
NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.
TLDR
Modified G-CSF signaling during stem cell mobilization augments NKT cell-dependent CD8+ cytotoxicity, effectively separating graft-versus-host disease and GVL and greatly expanding the potential applicability of allogeneic stem cell transplantation for the therapy of malignant disease.
Identification of a Cytotoxic T-Lymphocyte Response to the Novel BARF0 Protein of Epstein-Barr Virus: a Critical Role for Antigen Expression
TLDR
It is shown that the Epstein-Barr virus (EBV)-encoded BARF0 sequence includes an HLA A*0201-restricted cytotoxic T-lymphocyte (CTL) epitope, which might contribute to the escape of immune recognition from virus-specific CTLs present in the host.
Profiling the CD8low phenotype, an alternative career choice for CD8 T cells during primary differentiation
TLDR
It is argued that the CD8low phenotype is an alternative career choice for any naive CD8+ T cell during primary activation but that the probability of choosing this option is greatly enhanced by both IL‐4 and strong activation conditions.
Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.
TLDR
Insight is provided into the association of Nef with cellular structures and general differences in the interactions of the Nef proteins from HIV-1 and HIV-2 are revealed.
Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells.
TLDR
Analysis of the Ag-processing function, using a recombinant vaccinia virus to transiently express the EBV nuclear Ags, revealed that CD40L-treated BL cells consistently processed endogenously synthesized viral Ags for recognition by HLA class I-restricted, virus-specific CTLs.
Epstein-Barr nuclear antigen-3 and -4 interact with RBP-2N, a major isoform of RBP-J kappa in B lymphocytes.
TLDR
RT-PCR analysis of a panel of B cell lymphomas and lymphoblastoid cell lines demonstrated that higher levels ofRBP-2N were expressed, in comparison to RBP-J kappa, indicating that RBP -2N is a major isoform expressed in B cells.
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