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Acetylcholinesterase inhibitors from Stephania venosa tuber
The results suggest that the positive charge at the nitrogen of the tetrahydroisoquinoline portion, steric substitution at thenitrogen, planarity of the molecule or substitutions at C‐2, −3, −9, and −10 affect the AChE inhibitory activity of protoberberine alkaloids. Expand
Comparison of the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) and cocaine: asymmetric generalization.
The results indicate that stimulus substitution between MDMA and cocaine is asymmetric and suggest that although similarities exist between the stimulus actions of ecstasy and cocaine, differences might be explained by their differential effects on increasing synaptic concentrations of serotonin, dopamine, and/or norepinephrine. Expand
Piperine inhibits cytokine production by human peripheral blood mononuclear cells.
Piperine appears to have potential as an immunomodulatory agent for immune system suppression after significantly inhibited the production of these two cytokines by activated PBMCs in a dose-dependent manner. Expand
Stimulus effects of three sulfur-containing psychoactive agents
At the doses examined, 4-MTA and 4-MTMA appear to be MDMA-like agents, and 2C-T-7 seems best classified as a DOM-like hallucinogen, and these results provide additional data that extend the structure-activity relationships of phenylalkylamines and that are consistent with what little is currently known about the action of 4- MTA and2C- T-7 in humans. Expand
Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane.
Intraocular administration of 300 microg of 6d and 7d to ocular hypertensive monkeys was shown to reduce intraocular pressure, and compounds such as 6d should demonstrate minimal central effects at potentially useful therapeutic doses and offer useful leads for further development. Expand
Anti-androgenic effect of sesquiterpenes isolated from the rhizomes of Curcuma aeruginosa Roxb.
6 sesquiterpenes isolated from rhizomes of Curcuma aeruginosa Roxb showed anti-androgenic effect on in vitro and in vivo assays and is a potential lead compound for treatment of androgen-dependent disorders. Expand
Bisindole alkaloids and secoiridoids from Alstonia macrophylla Wall. ex G. Don.
The ethanolic extract from stems of a Thai medicinal plant, Alstonia macrophylla Wall, showed a significant inhibitory effect on acetylcholinesterase (AChE) determined by using Ellman assay, and compound 4 inhibited cell growth on human androgen-sensitive prostate cancer cell line (LNCaP) but no effect on viability of human foreskin fibroblast cells (HF). Expand
Evaluation of a new lead for acetylcholinesterase inhibition
Acetylcholine is the most common neurotransmitter of the parasympathetic nervous system. Several cholinergic drugs are widely used in Alzheimer’s disease, urinary retention, glaucoma, and myastheniaExpand
Curcumin analogues inhibit phosphodiesterase‐5 and dilate rat pulmonary arteries
Curcumin analogues are studied for PDE5 inhibitory activity and vasorelaxation of rat pulmonary arteries for the treatment of pulmonary arterial hypertension. Expand
Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats
The present findings are the first to demonstrate an MDMA-induced enhancing effect on the discriminative stimulus actions of a classical hallucinogen. Expand