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Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
TLDR
Results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol, and indicates that this trait is at least partly determined by genetic factors. Expand
Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
TLDR
The results evidenced that expression of bcl-2 oncoprotein in the CA1 area following brief ischemia is closely related to the acquisition of resistance to DND. Expand
Injection of digitally synthesized synaptic conductance transients to measure the integrative properties of neurons
TLDR
Cellular responses to synthetic conductance transients modelled on the fast (non-N-methyl-D-aspartate) phase of the glutamatergic postsynaptic potential were measured in cultured rat hippocampal neurons to allow quantitative measurement of the processing of synaptic inputs. Expand
Inhibitory control of intracerebellar nuclei by the Purkinje cell axons
TLDR
The postulate that the Purkinje cells exert an inhibitory action upon their target neurones thus applies not only to Deiters neurones, as previously proposed, but also to cells in the cerebellar nuclei. Expand
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia.
TLDR
The present results indicate that Naspm and JSTX are effective at blocking abnormal EPSCs that may induce Ca2+ accumulation leading to delayed neuronal death after transient ischemic insult. Expand
Nonstationary fluctuation analysis and direct resolution of single channel currents at postsynaptic sites.
TLDR
The results are the first measurements of the properties of single postsynaptic channels activated during synaptic currents, and suggest that the technique can be widely applicable in investigations of synaptic mechanism and plasticity. Expand
Intracellular inositol 1,3,4,5‐tetrakisphosphate enhances the calcium current in hippocampal CA1 neurones of the gerbil after ischaemia.
TLDR
The view that a disturbed phosphoinositide cascade occurs in the hippocampal pyramidal neurones after ischaemia and the InsP4 thus formed plays an important role in promoting the Ca2+ accumulation which results in neuronal death is supported. Expand
Disturbance of Membrane Function Preceding Ischemic Delayed Neuronal Death in the Gerbil Hippocampus
TLDR
The results indicate that ischemia-damaged CA1 neurons suffer from abnormal Ca2+ homeostasis, involving IP3-induced liberation of Ca2+. Expand
Ca(2+)-dependent non-NMDA receptor-mediated synaptic currents in ischemic CA1 hippocampal neurons.
TLDR
The changes in excitatory postsynaptic currents (EPSCs) after transient cerebral ischemia were studied using whole-cell recording from CA1 pyramidal neurons in gerbils and showed a markedly slowed time course that was never seen in normal control neurons. Expand
Spider toxin (JSTX-3) inhibits the convulsions induced by glutamate agonists
TLDR
Results indicate that JSTX-3 is a selective antagonist of the quisqualate receptors in the mammalian central nervous system. Expand
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