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Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
It is found that (+)-fusicocca-2,10 (14)-diene, a tricyclic hydrocarbon precursor for fusicoccins, is biosynthesized from the C5 isoprene units by an unusual multifunctional enzyme, P. amygdali fusICoccadiene synthase (PaFS), which shows both prenyltransferase and terpene cyclase activities.
Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
Combined treatment with rapamycin and cotylenin A significantly inhibited the growth of MCF-7 cells as xenografts, without apparent adverse effects, suggesting that this combination may have therapeutic value in treating breast cancer.
Erinacine Q, a New Erinacine from Hericium erinaceum, and its Biosynthetic Route to Erinacine C in the Basidiomycete
The search for new cyathane metabolites from a liquid culture of Hericium erinaceum YB4-6237 resulted in the isolation of a new erinacine named erinACine Q, which was determined to be a derivative in which the formyl group of er inacine P had been reduced to the hydroxymethyl group.
Antibacterial and Antifungal Activities of New Acylated Derivatives of Epigallocatechin Gallate
Addition of long alkyl chains to EGCG significantly enhanced its activities against several bacteria and fungi, particularly against S. aureus including MRSA, and might potentially become under specified circumstances an alternative or supplement to antibiotics and disinfectants in the future.
Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers.
Combined treatment with cotylenin-A and an anti-EGFR antibody synergistically suppresses tumor growth in vitro and in vivo and defines a novel pharmacologic strategy for treatment of RAS mutant cancers.
Photochromism of 1,2-Bis(2,5-dimethyl-3-thienyl)perfluoro- cyclopentene in a Single Crystalline Phase
1,2-Bis(2,5-dimethyl-3-thienyl)perfluorocyclopentene (1a) was found to undergo photochromism in a single crystalline phase. Upon irradiation with ultraviolet light the colorless crystal turned red
Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells.
Results show that synergistic cell death induced by the combined treatment with CN-A and PEITC is mainly due to the induction of ferroptosis, which has potential as a novel therapeutic strategy against pancreatic cancer.
Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase.
N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0