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Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice
PTSD-like memory impairments in rodents are demonstrated and a potential pathophysiological mechanism of this condition is identified.
BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids
The tPA-BDNF-TrkB signaling pathway is identified as the upstream molecular effectors of GR-mediated phosphorylation of Erk1/2MAPK responsible for the enhancement of contextual fear memory and is highlighted as one of the core effector of stress-related effects of GC.
The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib
The data provide a complete molecular pathway through which stress and glucocorticoids enhance the memory of stress-related events and highlight the function of synapsin-Ia/Ib as molecular effector of the behavioral effects of stress.
Central amygdala circuit dynamics underlying the benzodiazepine anxiolytic effect
It is proposed that BZDs block the relay of aversive signals through the CEA, in part by local binding to CEAl SST + /PKCδ − neurons and reshaping intra-CEA circuit dynamics.
Glucocorticoid treatment induces expression of Egr-1 and synapsin-I proteins in primary culture of hippocampal neurons
It is found that glucocorticoid treatment induces expression of Egr-1 and synapsin-I proteins in primary culture of hippocampal neurons and this results in a down-regulation in the expression of these proteins in the hippocampus.
Early perceptual loss in depression
False Opposing Fear Memories Are Produced as a Function of the Hippocampal Sector Where Glucocorticoid Receptors Are Activated
- N. Kaouane, Eva-Gunnel Ducourneau, A. Marighetto, M. Segal, A. Desmedt
- Psychology, BiologyFrontiers in Behavioral Neuroscience
- 26 August 2020
Findings demonstrate that false opposing fear memories can be produced depending on the hippocampal sector in which the GRs are activated, and are both mediated by glucocorticoid receptor (GR) activation, and reproduced by post-conditioning stress or systemic CORT injection.
Maternal and neonatal behaviors of Ouled Djellal sheep breed and their effects on production parameters
39th Annual European Brain and Behaviour Society Abstracts
All approaches relating brain and behaviour were represented at the meeting, which aimed to further expand the wide spectrum of previous EBBS AGMs, and to bring together integrative, system, cognitive, computational neuroscientists.
Spectral recording of gene expression history by fluorescent timer protein.
This work fuse a fluorescent timer protein with an immediate early gene (IEG) promoter to track live gene expression in single cells, resulting in a stimulus- and time-dependent spectral shift from blue to red for subsequent monitoring with fluorescence activated cell sorting (FACS) and live cell imaging.