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Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp.
TLDR
The results suggest that plasmin activates PAR-1 and is involved in inflammation in human dental pulp. Expand
MMP‐3 provokes CTGF/CCN2 production independently of protease activity and dependently on dynamin‐related endocytosis, which contributes to human dental pulp cell migration
TLDR
It is strongly suggested that MMP‐3 induces CTGF/CCN2 production independently of the protease activity of M MP‐3 and dependently on dynamin‐related endocytosis, which is involved in cell migration in human dental pulp cells. Expand
Protein kinase C synergistically stimulates tumor necrosis factor-alpha-induced secretion of urokinase-type plasminogen activator in human dental pulp cells.
TLDR
It is suggested that protein kinase C synergistically enhances the secretion of uPA in TNF-alpha-stimulated human dental pulp cells. Expand
IL-1β stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells
TLDR
It is suggested that IL-1beta stimulates uPA production via activation of NFkappaB and tyrosine phosphorylation, and also secretion of the enzyme, and that the uPA/plasmin system appears to be involved in inflammation in human dental pulp. Expand
CCN2/CTGF expression via cellular uptake of BMP-1 is associated with reparative dentinogenesis.
TLDR
CCN2/CTGF and BMP-1 coexist beneath caries lesion and CCN2/(CTGF) expression is regulated by dynamin-related cellular uptake of B MP-1, which suggests a novel property of metalloprotease in reparative dentinogenesis. Expand
Role of CTGF/CCN2 in reparative dentinogenesis in human dental pulp.
TLDR
The data suggest that CTGF/CCN2 is likely involved in reparative dentinogenesis through formation of hard tissue in human carious teeth. Expand
Metalloproteases and CCN2/CTGF in dentin–pulp complex repair
Abstract Background Metalloproteases are widely regarded as catalytic enzymes involved in extracellular matrix remodeling in the dental pulp. However, cells internalize several metalloproteases,Expand
Tumor necrosis factor α stimulates expression and secretion of urokinase plasminogen activator in human dental pulp cells.
TLDR
It is suggested that TNF-α stimulates uPA production and secretion, and that this effect is regulated via activation of NFκB and tyrosine phosphorylation, apparently in conjunction with IL-1β, during inflammation in human dental pulp. Expand
IL-1beta stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells.
TLDR
It is suggested that IL-1beta stimulates uPA production via activation of NFkappaB and tyrosine phosphorylation, and also secretion of the enzyme, and that the uPA/plasmin system appears to be involved in inflammation in human dental pulp. Expand
Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease‐Activated Receptor‐1
TLDR
The data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease‐activated receptor 1, and that SCH79797, an antagonist of protease-activated receptor‐1, blocked these effects. Expand
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